Decarboxylase inhibition and blood pressure reduction by alpha-methyl-3,4-dihydroxy-DL-phenylalanine.

Science (New York, N.Y.) ·Vol. 131 ·No. 3417 ·1960-06-24 ·Pages 1890-1

OATES JA, GILLESPIE L, UDENFRIEND S, SJOERDSMA A

Abstract

alpha-Methyl-3,4-dihydroxy-DLphenylalanine has been found to be an effective inhibitor of aromatic amino acid decarboxylation in man. This was shown by decreased formation of serotonin, tryptamine, and tyramine from the precursor amino acids. Reduction of amine biosynthesis is associated with lowering of blood pressure in hypertensive patients and a transient sedative effect.

Keywords

BLOOD PRESSURE/pharmacology DESMOLASES/metabolism PHENYLALANINE/related compounds

MeSH Terms

Amino Acids Blood Pressure/pharmacology Carboxy-Lyases Humans Lyases/metabolism Male Phenylalanine/analogs & derivatives Serotonin

Chemicals

Amino Acids Serotonin Phenylalanine Lyases Carboxy-Lyases

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

OATES J A

GILLESPIE L

UDENFRIEND S

SJOERDSMA A

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.131.3417.1890

Published

1960-06-24

Pages

1890-1

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.131.3417.1890 View journal details

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Decarboxylase inhibition and blood pressure reduction by alpha-methyl-3,4-dihydroxy-DL-phenylalanine.

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