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PMID: 144048 Published · ppublish English Journal Article

Variations in the length of S-phase related to the time cells are blocked at the G1-S interface.

Chromosoma ·Vol. 63 ·No. 1 ·1977-08-18 ·Pages 33-7

Carnevali F, Mariotti D

Abstract

The inhibition of DNA synthesis with hydroxyurea or 5-fluorode-oxyuridine decreases the duration of S-phase of synchronously growing Chinese hamster cultures. - The observed drug effects are discussed in relation to an alteration of programmed DNA replication.

MeSH Terms
Cells, Cultured DNA Replication/drug effects Floxuridine/pharmacology Hydroxyurea/pharmacology Mitosis/drug effects Time Factors
Chemicals
Floxuridine Hydroxyurea
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Carnevali F
Mariotti D
References (9)
9 references, click to expand
  1. On the mechanism of DNA replication in mammalian chromosomes.
    J Mol Biol. 1968 Mar 14;32(2):327-41 PMID: 5689363
  2. Replicon origins in Chinese hamsters cell DNA. I. Labeling procedure and preliminary observations.
    Exp Cell Res. 1972 Oct;74(2):367-74 PMID: 4263528
  3. Distribution of DNA replicator sites in mammalian nuclei. II. Effects of prolonged inhibition of DNA synthesis.
    Exp Cell Res. 1972 Jan;70(1):203-13 PMID: 4257609
  4. Replication of DNA in mammalian chromosomes. IV. Partial characterization of DNA fragments released from replicating DNA of CHO cells.
    Exp Cell Res. 1977 Jan;104(1):7-14 PMID: 12992
  5. Purified cytoplasmic DNA from HeLa cells: resistance to inhibition by hydroxyurea.
    Biochem Biophys Res Commun. 1969 Apr 29;35(2):249-57 PMID: 5783446
  6. The comparative effects of short-term DNA Inhibition on replicon synthesis in mammalian cells.
    Exp Cell Res. 1976 Dec;103(2):361-73 PMID: 137123
  7. Sequence programming of DNA replication over the S phase of Chinese hamster cells.
    Exp Cell Res. 1977 Jan;104(1):47-54 PMID: 137816
  8. S phase synchrony in monolayer CHO cultures.
    Exp Cell Res. 1976 Jul;100(2):265-75 PMID: 939252
  9. Replicon origins in Chinese hamster cell DNA. II. Reproducibility.
    Exp Cell Res. 1973 Jul;80(1):79-87 PMID: 4274005
Article Info
Journal
Chromosoma
Abbr.
Chromosoma
ISSN
0009-5915
DOI
10.1007/BF00292940
Published
1977-08-18
Pages
33-7
Language
English
Region
Austria
NLM ID
2985138R
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00292940 View journal details
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