RATE OF UTILIZATION OF GLUCOSE AND 'COMPARTMENTATION' OF ALPHA-OXOGLUTARATE AND GLUTAMATE IN RAT BRAIN.
1. The rate of incorporation of (14)C into pyruvate, alpha-oxoglutarate, lactate and glucose of rat tissues was measured after the subcutaneous injection of uniformly labelled glucose. 2. In rat brain the specific radioactivities of lactate and glucose were similar to that of alanine. In liver the specific radioactivity of glucose was considerably higher than that of lactate or alanine. 3. The specific radioactivities of alpha-oxo acids of rat brain were lower than those of corresponding amino acids, alanine and glutamate. These findings have been explained in relation to metabolic compartments in vivo. 4. The approximate estimated rate of glucose utilization in rat brain in vivo is 0.96mumole/g. of brain/min.
17 references, click to expand
-
Separation and estimation of blood keto acids by paper chromatography.Biochem J. 1953 Feb;53(3):340-7 PMID: 13032076
-
The incorporation in vitro of C14 into amino acids of control and virus-infected mouse brain.J Biol Chem. 1953 Jan;200(1):357-65 PMID: 13034793
-
The concentration of glucose in rat tissues.Biochem J. 1956 Sep;64(1):145-50 PMID: 13363818
-
AMINO ACID METABOLISM IN RAT BRAIN STUDIED WITH 14C-LABELLED GLUCOSE.J Neurochem. 1964 Mar;11:165-85 PMID: 14165154
-
The photometric microdetermination of blood glucose with glucose oxidase.J Lab Clin Med. 1958 Mar;51(3):448-60 PMID: 13514258
-
The conversion of glucose carbon into protein in the brain and other organs of the rat.J Neurochem. 1962 Sep-Oct;9:465-75 PMID: 13998013
-
Detection of sugars on paper chromatograms.Nature. 1950 Sep 9;166(4219):444-5 PMID: 14775715
-
THE METABOLISM OF GLUTAMATE IN HOMOGENATES AND SLICES OF BRAIN CORTEX.Biochem J. 1963 Sep;88:566-78 PMID: 14071531
-
THE UTILIZATION OF GLUCOSE IN THE BRAIN AND OTHER ORGANS OF THE CAT.Proc R Soc Lond B Biol Sci. 1964 Apr 14;160:124-36 PMID: 14142165
-
Carbon dioxide fixation in the brain.J Biol Chem. 1962 Aug;237:2570-3 PMID: 13867915
-
The composition of brain lipoprotein fractions obtained by different procedures.J Neurochem. 1961 Dec;8:234-42 PMID: 13896260
-
Studies in vitamin A. XIIX. The effect of vitamin A deficiency on the pyruvate and ketoglutarate levels of rat blood.Biochem J. 1952 Aug;51(5):708-14 PMID: 13018148
-
Measurements of ketoacids in normal and neoplastic rat tissue.Cancer Res. 1950 Jun;10(6):393-7 PMID: 15420710
-
Body size and tissue respiration.Biochim Biophys Acta. 1950 Jan;4(1-3):249-69 PMID: 15403932
-
EXCHANGE TRANSAMINATION AND THE METABOLISM OF GLUTAMATE IN BRAIN.Biochem J. 1965 Jan;94:131-41 PMID: 14342220
-
Quantitative determination of keto-acids by paper partition chromatography.Biochim Biophys Acta. 1954 Mar;13(3):439-45 PMID: 13140357
-
ENTRY OF GLUCOSE CARBON INTO AMINO ACIDS OF RAT BRAIN AND LIVER IN VIVO AFTER INJECTION OF UNIFORMLY 14-C-LABELLED GLUCOSE.Biochem J. 1965 Feb;94:345-52 PMID: 14348195
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: product@genelibs.com
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
