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PMID: 14276123 Published · ppublish English Journal Article

DRUG RESISTANCE OF STAPHYLOCOCCI. I. TRANSDUCTION OF TETRACYCLINE RESISTANCE WITH PHAGE LYSATES OBTAINED FROM MULTIPLY RESISTANT STAPHYLOCOCCI.

Journal of bacteriology ·Vol. 89 ·1965-04-00 ·Pages 967-76

MITSUHASHI S, OSHIMA H, KAWAHARADA U, HASHIMOTO H

Abstract

Mitsuhashi, Susumu (Gunma University, Maebashi, Japan), Hiroshi Oshima, Umeko Kawaharada, and Hajime Hashimoto. Drug resistance of staphylococci. I. Transduction of tetracycline resistance with phage lysates obtained from multiply resistant staphylococci. J. Bacteriol. 89:967-976. 1965.-Tetracycline resistance was found to be transduced with phage lysates obtained from multiply resistant strains of Staphylococcus aureus of human origin. With various combinations of multiply resistant donors and tetracycline (TC)-sensitive recipients, almost all of the strains were found to be competent donors. A greater percentage of group 1 staphylococci were competent recipients. Most of the TC(+) transductants were not lysogenic for the transducing phage and were unable to transduce TC resistance with their own phage lysates obtained by ultraviolet irradiation. However, the TC(+) transductants, lysogenized with transducing phage, were capable of transducing TC resistance, and some of the lysogenizations were accompanied by changes in phage type. These results suggest that the emergence of the multiply resistant staphylococci (consistently resistant to TC) can be accounted for by transduction among various strains accompanied sometimes by changes in phage typing pattern after lysogenization, and by selection through extensive use of antibiotics and chemotherapeutic agents.

Keywords
BACTERIOPHAGE DRUG RESISTANCE MICROBIAL EXPERIMENTAL LAB STUDY STAPHYLOCOCCUS TETRACYCLINE
MeSH Terms
Anti-Bacterial Agents Bacteriophage Typing Bacteriophages Drug Resistance, Microbial Japan Research Staphylococcal Infections Staphylococcus Staphylococcus aureus Tetracycline Tetracycline Resistance
Chemicals
Anti-Bacterial Agents Tetracycline
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
MITSUHASHI S
OSHIMA H
KAWAHARADA U
HASHIMOTO H
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.89.4.967-976.1965
Published
1965-04-00
Pages
967-76
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC277580
Subset
OM
External Links
PubMed source DOI: 10.1128/jb.89.4.967-976.1965 PMC Full Text View journal details
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