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PMID: 14208194 Published · ppublish English Journal Article

THE EFFECTS OF ADRENALINE AND OTHER DRUGS AFFECTING CARBOHYDRATE METABOLISM ON CONTRACTIONS OF THE RAT DIAPHRAGM.

British journal of pharmacology and chemotherapy ·Vol. 23 ·1964-08-00 ·Pages 184-200

BOWMAN WC, RAPER C

Abstract

The ability of several drugs to restore directly elicited twitches of the rat diaphragm depressed by excess potassium chloride has been studied. The drugs found to be effective were sympathomimetic amines, insulin, glucagon, caffeine, theophylline, calcium chloride and hexosephosphates. The effects of the sympathomimetic amines and glucagon were blocked by beta-receptor blocking agents. Phloridzin blocked the effect of insulin and depressed that of glucagon. The increase in twitch tension still occurred under anaerobic conditions and was not abolished by the glycolytic inhibitor, iodoacetate. All of the effective drugs are known to affect carbohydrate metabolism and the suggestion by Ellis (1955) that the effect on contractions may be a result of increased intracellular hexosephosphate levels is discussed.

Keywords
CAFFEINE CALCIUM CHLORIDE CARBOHYDRATE METABOLISM DIAPHRAGM DOPAMINE EPHEDRINE EPINEPHRINE EXPERIMENTAL LAB STUDY GLUCAGON HEXOSEPHOSPHATES INSULIN IODOACETATES ISOPROTERENOL MUSCLE SMOOTH NOREPINEPHRINE PHARMACOLOGY PHLORHIZIN RATS SYMPATHOMIMETICS THEOPHYLLINE TYRAMINE
MeSH Terms
Caffeine Calcium Chloride Carbohydrate Metabolism Diaphragm Dopamine Ephedrine Epinephrine Glucagon Hexosephosphates Insulin Iodoacetates Isoproterenol Muscle, Smooth Muscles Norepinephrine Pharmacology Phlorhizin Rats Research Sympathomimetics Theophylline Tyramine
Chemicals
Hexosephosphates Insulin Iodoacetates Sympathomimetics Caffeine Glucagon Theophylline Phlorhizin Ephedrine Isoproterenol Calcium Chloride Dopamine Norepinephrine Tyramine Epinephrine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
BOWMAN W C
RAPER C
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35 references, click to expand
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Article Info
Journal
British journal of pharmacology and chemotherapy
Abbr.
Br J Pharmacol Chemother
ISSN
0366-0826
DOI
10.1111/j.1476-5381.1964.tb01578.x
Published
1964-08-00
Pages
184-200
Language
English
Region
England
NLM ID
0154627
PMCID
PMC1703966
Subset
OM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1964.tb01578.x PMC Full Text
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