Home LiteratureArticle Details

PMID: 1419632 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water.

British journal of cancer ·Vol. 66 ·No. 5 ·1992-11-00 ·Pages 888-92

Chen CJ, Chen CW, Wu MM, Kuo TL

Abstract

In order to compare risk of various internal organ cancers induced by ingested inorganic arsenic and to assess the differences in risk between males and females, cancer potency indices were calculated using mortality rates among residents in an endemic area of chronic arsenicism on the southwest coast of Taiwan, and the Armitage-Doll multistage model. Based on a total of 898,806 person-years as well as 202 liver cancer, 304 lung cancer, 202 bladder cancer and 64 kidney cancer deaths, a significant dose-response relationship was observed between arsenic level in drinking water and mortality of the cancers. The potency index of developing cancer of the liver, lung, bladder and kidney due to an intake of 10 micrograms kg day of arsenic was estimated as 4.3 x 10(-3), 1.2 x 10(-2), 1.2 x 10(-2), and 4.2 x 10(-3), respectively, for males; as well as 3.6 x 10(-3), 1.3 x 10(-2), 1.7 x 10(-2), and 4.8 x 10(-3), respectively, for females in the study area. The multiplicity of inorganic arsenic-induced carcinogenicity without showing any organotropism deserves further investigation.

MeSH Terms

Adult Aged Arsenic/toxicity Female Humans Kidney Neoplasms/chemically induced,epidemiology,mortality Liver Neoplasms/chemically induced,epidemiology,mortality Lung Neoplasms/chemically induced,epidemiology,mortality Male Middle Aged Models, Statistical Organ Specificity Risk Factors Sex Factors Taiwan/epidemiology Urinary Bladder Neoplasms/chemically induced,epidemiology,mortality Water Supply/analysis

Chemicals

Arsenic

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Chen C J

Institute of Public Health, National Taiwan University College of Medicine, Taipei, ROC.

Chen C W

Wu M M

Kuo T L

References (20)

20 references, click to expand

Cigarette smoking and bronchial carcinoma: dose and time relationships among regular smokers and lifelong non-smokers.
J Epidemiol Community Health. 1978 Dec;32(4):303-13 PMID: 744822
Metabolism of 74As-labeled trivalent and pentavalent inorganic arsenic in mice.
Environ Res. 1980 Apr;21(2):446-57 PMID: 7408817
Ecological correlation between arsenic level in well water and age-adjusted mortality from malignant neoplasms.
Cancer Res. 1990 Sep 1;50(17):5470-4 PMID: 2386951
Allelotype of colorectal carcinomas.
Science. 1989 Apr 14;244(4901):207-11 PMID: 2565047
Differential DNA sequence deletions from chromosomes 3, 11, 13, and 17 in squamous-cell carcinoma, large-cell carcinoma, and adenocarcinoma of the human lung.
Proc Natl Acad Sci U S A. 1989 Jul;86(13):5099-103 PMID: 2567993
Dose-response relation between arsenic concentration in well water and mortality from cancers and vascular diseases.
Am J Epidemiol. 1989 Dec;130(6):1123-32 PMID: 2589305
A dose-response analysis of skin cancer from inorganic arsenic in drinking water.
Risk Anal. 1989 Dec;9(4):519-28 PMID: 2608947
Multistage modeling of lung cancer mortality among arsenic-exposed copper-smelter workers.
Risk Anal. 1989 Dec;9(4):551-63 PMID: 2608948
Arsenic and cancers.
Lancet. 1988 Feb 20;1(8582):414-5 PMID: 2893213
Atherogenicity and carcinogenicity of high-arsenic artesian well water. Multiple risk factors and related malignant neoplasms of blackfoot disease.
Arteriosclerosis. 1988 Sep-Oct;8(5):452-60 PMID: 3190552
The origins of human cancer: molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment--twenty-seventh G.H.A. Clowes memorial award lecture.
Cancer Res. 1988 Aug 1;48(15):4135-43 PMID: 3292040
Induction of gene amplification by arsenic.
Science. 1988 Jul 1;241(4861):79-81 PMID: 3388020
A retrospective study on malignant neoplasms of bladder, lung and liver in blackfoot disease endemic area in Taiwan.
Br J Cancer. 1986 Mar;53(3):399-405 PMID: 3964542
Malignant neoplasms among residents of a blackfoot disease-endemic area in Taiwan: high-arsenic artesian well water and cancers.
Cancer Res. 1985 Nov;45(11 Pt 2):5895-9 PMID: 4053060
Prevalence of skin cancer in an endemic area of chronic arsenicism in Taiwan.
J Natl Cancer Inst. 1968 Mar;40(3):453-63 PMID: 5644201
Implications of the multistage theory of carcinogenesis applied to occupational arsenic exposure.
J Natl Cancer Inst. 1983 Mar;70(3):455-63 PMID: 6572736
Urinary excretion of inorganic arsenic and its metabolites after repeated ingestion of sodium metaarsenite by volunteers.
Int Arch Occup Environ Health. 1981;48(2):111-8 PMID: 6894910
Mutation and cancer: a model for human carcinogenesis.
J Natl Cancer Inst. 1981 Jun;66(6):1037-52 PMID: 6941039
Mortality studies of smelter workers.
Am J Ind Med. 1980;1(3-4):251-9 PMID: 7342769
A stochastic two-stage carcinogenesis model: a new approach to computing the probability of observing tumor in animal bioassays.
Math Biosci. 1991 May;104(2):247-58 PMID: 1804462

Article Info

Journal

British journal of cancer

Abbr.

Br J Cancer

ISSN

0007-0920

DOI

10.1038/bjc.1992.380

Published

1992-11-00

Pages

888-92

Language

English

Region

England

NLM ID

0370635

PMCID

PMC1977977

Subset

External Links

PubMed source DOI: 10.1038/bjc.1992.380 PMC Full Text View journal details

Analysis Services

Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water.

Contact

WeChat Official Account