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PMID: 14190477 Published · ppublish English Journal Article

EFFECTS OF CENTRAL DEPRESSANT DRUGS UPON ACETYLCHOLINE RELEASE.

British journal of pharmacology and chemotherapy ·Vol. 22 ·1964-04-00 ·Pages 415-40

MATTHEWS EK, QUILLIAM JP

Abstract

Several central depressant and other drugs have been examined for their effects upon acetylcholine release from the stimulated, perfused cat superior cervical ganglion and rat isolated phrenic nerve-diaphragm preparations. The acetylcholine released was assayed biologically. Amylobarbitone sodium, chloral hydrate, trichloroethanol, methylpentynol, methylpentynol carbamate, paraldehyde, procaine hydrochloride and troxidone reduced the presynaptic release of acetylcholine from the ganglion. They also exhibited a postsynaptic blocking action, this component of depressant activity being particularly prominent with paraldehyde and troxidone. Closely analogous findings were obtained at the neuromuscular junction with methylpentynol and its carbamate, paraldehyde, procaine hydrochloride, trichloroethanol and troxidone. At both sites the drug-induced depression, both of transmission and of acetylcholine output, was reversible. Whereas hexamethonium regularly blocked ganglionic transmission with no effect upon acetylcholine release, tetraethylammonium not only completely blocked ganglionic transmission but concomitantly augmented acetylcholine output. These results are discussed in relation to the electrophysiological and metabolic events associated with neuro-effector transmission.

Keywords
ACETYLCHOLINE ANESTHETICS ANTICONVULSANTS DIAPHRAGM EXPERIMENTAL LAB STUDY GANGLIA SPINAL GANGLIONIC BLOCKADERS HEPARIN HYPNOTICS AND SEDATIVES NEUROMUSCULAR JUNCTION PHRENIC NERVE RATS URETHANE
MeSH Terms
Acetylcholine Anesthetics Animals Anticonvulsants Cats Chloral Hydrate Diaphragm Ganglia Ganglia, Spinal Ganglionic Blockers Heparin Hypnotics and Sedatives Neuromuscular Junction Paraldehyde Phrenic Nerve Procaine Rats Research Urethane
Chemicals
Anesthetics Anticonvulsants Ganglionic Blockers Hypnotics and Sedatives Urethane Chloral Hydrate Procaine Heparin Acetylcholine Paraldehyde
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
MATTHEWS E K
QUILLIAM J P
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36 references, click to expand
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Article Info
Journal
British journal of pharmacology and chemotherapy
Abbr.
Br J Pharmacol Chemother
ISSN
0366-0826
DOI
10.1111/j.1476-5381.1964.tb02047.x
Published
1964-04-00
Pages
415-40
Language
English
Region
England
NLM ID
0154627
PMCID
PMC1703980
Subset
OM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1964.tb02047.x PMC Full Text
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