SKIN TUMORIGENESIS BY 7,12-DIMETHYLBENZ(A)ANTHRACENE: INHIBITION BY ACTINOMYCIN D.

Science (New York, N.Y.) ·Vol. 145 ·No. 3638 ·1964-09-18 ·Pages 1321-2

GELBOIN HV, KLEIN M

Abstract

Topical application of actinomycin D during a short period of time immediately before and after a single application of 7, 12-dimethyl-benz (a)anthracene markedly inhibits subsequent tumor formation. The results indicate that the initial events of carcinogenesis are dependent on DNA-dependent RNA synthesis.

Keywords

ACTINOMYCIN ANTINEOPLASTIC AGENTS BENZANTHRACENES CARCINOGENS EXPERIMENTAL LAB STUDY MICE PHARMACOLOGY SKIN NEOPLASMS TOXICOLOGIC REPORT

MeSH Terms

Animals Anthracenes Antineoplastic Agents Benz(a)Anthracenes Carcinogenesis Carcinogens Dactinomycin Mice Neoplasms, Experimental Pharmacology Research Skin Neoplasms Toxicology

Chemicals

Anthracenes Antineoplastic Agents Benz(a)Anthracenes Carcinogens Dactinomycin benz(a)anthracene anthracene

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

GELBOIN H V

KLEIN M

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.145.3638.1321

Published

1964-09-18

Pages

1321-2

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.145.3638.1321 View journal details

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SKIN TUMORIGENESIS BY 7,12-DIMETHYLBENZ(A)ANTHRACENE: INHIBITION BY ACTINOMYCIN D.

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