FLUORIDE: ITS EFFECTS ON 2 PARAMETERS OF BONE GROWTH IN ORGAN CULTURE.

Science (New York, N.Y.) ·Vol. 145 ·No. 3635 ·1964-08-28 ·Pages 932-4

PROFFIT WR, ACKERMAN JL

Abstract

Bones of the forepaws of young rats were subjected to varying concentrations of fluoride ions in organ culture. The formation of DNA and protein synthesis were evaluated by measurements of the uptake of tritiated thymidine and C(14)-labeled proline. Fluoride concentrations as high as 10 to 20 parts per million had no demonstrable effect in vitro on these basic parameters of skeletal growth

Keywords

BONE AND BONES CARBON ISOTOPES CELL DIVISION DNA EPIPHYSES EXPERIMENTAL LAB STUDY FLUORIDES METACARPUS PHARMACOLOGY PROLINE PROTEIN METABOLISM RADIOAUTOGRAPHY RATS THYMIDINE TISSUE CULTURE TRITIUM

MeSH Terms

Autoradiography Bone Development Bone and Bones Carbon Isotopes Cell Division DNA Epiphyses Fluorides Metacarpus Organ Culture Techniques Pharmacology Phosphates Proline Proteins/metabolism Rats Research Thymidine Tissue Culture Techniques Tritium

Chemicals

Carbon Isotopes Phosphates Proteins Tritium fluorophosphate DNA Proline Fluorides Thymidine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

PROFFIT W R

ACKERMAN J L

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.145.3635.932

Published

1964-08-28

Pages

932-4

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.145.3635.932 View journal details

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FLUORIDE: ITS EFFECTS ON 2 PARAMETERS OF BONE GROWTH IN ORGAN CULTURE.

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