ATROPHY OF SKELETAL MUSCLE IN CHICK EMBRYOS TREATED WITH BOTULINUM TOXIN.

Science (New York, N.Y.) ·Vol. 145 ·No. 3633 ·1964-08-14 ·Pages 719-21

DRACHMAN DB

Abstract

Botulinum toxin was given in large intravenous doses to 7- and 12- day chick embryos. Atrophy of skeletal muscle resulted without significant atrophy of other organs. The histological appearance of muscle was consistent with denervation. The results suggest that neural acetylcholine release may play a significant role in "trophic transmission" from nerve to muscle.

Keywords

ABNORMALITIES DRUG-INDUCED ACETYLCHOLINE CHICK EMBRYO CLOSTRIDIUM BOTULINUM EXPERIMENTAL LAB STUDY JOINT DISEASES MUSCLES MUSCULAR ATROPHY NEUROMUSCULAR JUNCTION PATHOLOGY TOXICOLOGIC REPORT TOXINS AND ANTITOXINS

MeSH Terms

Abnormalities, Drug-Induced Acetylcholine Antitoxins Botulinum Toxins Chick Embryo Clostridium botulinum Joint Diseases Muscle, Skeletal Muscles Muscular Atrophy Neuromuscular Junction Pathology Research Toxicology Toxins, Biological

Chemicals

Antitoxins Toxins, Biological Botulinum Toxins Acetylcholine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

DRACHMAN D B

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.145.3633.719

Published

1964-08-14

Pages

719-21

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.145.3633.719 View journal details

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ATROPHY OF SKELETAL MUSCLE IN CHICK EMBRYOS TREATED WITH BOTULINUM TOXIN.

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