THERAPEUTIC ANTIVIRAL ACTION OF 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE IN HERPES SIMPLEX KERATITIS.

Science (New York, N.Y.) ·Vol. 145 ·No. 3632 ·1964-08-07 ·Pages 585-6

KAUFMAN HE, HEIDELBERGER C

Abstract

5-Trifluoromethyl-2'-deoxyuridine (F(3)TDR) has potent therapeutic antiviral activity in herpes simplex infection of the rabbit cornea with strains of herpes virus both sensitive and resistant to 5-iodo-2'-deoxyuridine, and in corneal infection with vaccinia. 5-Trifluoromethyl uracil is not therapeutically active in herpetic keratitis.

Keywords

ANTIVIRAL AGENTS CORNEA CORNEAL ULCER EXPERIMENTAL LAB STUDY IDOXURIDINE KERATITIS DENDRITIC PHARMACOLOGY RABBITS ULCER VACCINIA

MeSH Terms

Animals Antiviral Agents Cornea Corneal Ulcer Idoxuridine Keratitis Keratitis, Dendritic Keratitis, Herpetic Pharmacology Rabbits Research Trifluridine Ulcer Vaccinia Vaccinia virus

Chemicals

Antiviral Agents 5'-deoxy-5'-iodouridine Idoxuridine Trifluridine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

KAUFMAN H E

HEIDELBERGER C

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.145.3632.585

Published

1964-08-07

Pages

585-6

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.145.3632.585 View journal details

Analysis Services

THERAPEUTIC ANTIVIRAL ACTION OF 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE IN HERPES SIMPLEX KERATITIS.

Contact

WeChat Official Account