DNA CONTENTS OF CHROMOSOME PH1 AND CHROMOSOME 21 IN HUMAN CHRONIC GRANULOCYTIC LEUKEMIA.

Science (New York, N.Y.) ·Vol. 144 ·No. 3623 ·1964-06-05 ·Pages 1229-31

RUDKIN CT, HUNGERFORD DA, NOWELL PC

Abstract

The Philadelphia chromosome, characteristic of chronic granulocytic leukemia, contained 61+/-1 percent as much DNA as a number 21 (or 22) chromosome from which it is believed to be derived. The remaining 39 percent represents 0.5 percent of a diploid chromosome complement, approximately 2 x 10(7) nucleotide pairs; the method used was not sensitive enough to detect whether it had been translocated to other chromosomes.

Keywords

CELL NUCLEUS CHROMOSOMES DNA NEOPLASM GENETICS LEUKEMIA MYELOCYTIC PATHOLOGY

MeSH Terms

Cell Nucleus Chromosomes Chromosomes, Human, 21-22 and Y Chromosomes, Human, 6-12 and X Chromosomes, Human, Pair 21 DNA DNA, Neoplasm Genetics Humans Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive Leukemia, Myeloid Neoplasms Pathology Philadelphia Chromosome Ploidies Translocation, Genetic

Chemicals

DNA, Neoplasm DNA

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

RUDKIN C T

HUNGERFORD D A

NOWELL P C

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.144.3623.1229

Published

1964-06-05

Pages

1229-31

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.144.3623.1229 View journal details

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