A USEFUL PHOTOMETRIC TEST FOR THE DIAGNOSIS OF VON WILLEBRAND'S DISEASE.

Journal of clinical pathology ·Vol. 17 ·1964-03-00 ·Pages 191-3

VAINER H, CAEN JP

Abstract

When small amounts of adenosine diphosphate are added to citrated platelet-rich plasma, the consequent modification of platelets leads to a decrease in optical density. In Von Willebrand's disease the optical density at 610 mmu increases instead of decreasing. This finding is used to study the effects of treatment on this disorder.

Keywords

ADENINE NUCLEOTIDES BLOOD COAGULATION FACTORS BLOOD COAGULATION TESTS BLOOD PLATELET DISORDERS BLOOD PLATELETS BLOOD TRANSFUSION DIAGNOSIS LABORATORY PHOTOMETRY PREDNISONE VON WILLEBRAND'S DISEASE

MeSH Terms

Adenine Nucleotides Blood Coagulation Factors Blood Coagulation Tests Blood Platelet Disorders Blood Platelets Blood Transfusion Clinical Laboratory Techniques Humans Photometry Prednisone von Willebrand Diseases

Chemicals

Adenine Nucleotides Blood Coagulation Factors Prednisone

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

VAINER H

CAEN J P

References (9)

9 references, click to expand

MEASUREMENT OF PLATELET ADHESIVENESS. A SIMPLE IN VITRO TECHNIQUE DEMONSTRATING AN ABNORMALITY IN VON WILLEBRAND'S DISEASE.
J Lab Clin Med. 1963 Nov;62:724-35 PMID: 14078008
Platelet aggregation: Part I Some effects of the adenosine phosphates, thrombin, and cocaine upon platelet adhesiveness.
J Clin Pathol. 1962 Sep;15(5):446-52 PMID: 16810985
[Use of a photometric test for the study of the effect of ADP on blood platelets].
Nouv Rev Fr Hematol. 1963 Mar-Apr;3:149-57 PMID: 13995761
Aggregation of blood platelets by adenosine diphosphate and its reversal.
Nature. 1962 Jun 9;194:927-9 PMID: 13871375
Adenosine diphosphate in red cells as a factor in the adhesiveness of human blood platelets.
Nature. 1961 Nov 11;192:531-2 PMID: 13896038
["In vivo" disorder of platelet adhesiveness in Willebrand's disease and Glanzmann's thrombasthenias. Trial interpretation].
Nouv Rev Fr Hematol. 1962 Sep-Oct;2:685-94 PMID: 14017640
Von Willebrand's disease and its correction with human plasma fraction 1-0.
Acta Med Scand. 1957 Nov 29;159(3):179-88 PMID: 13508084
Transfusion studies in von Willebrand's disease: effect on bleeding time and factor VIII.
Br J Haematol. 1963 Apr;9:189-202 PMID: 14023112
In vitro abnormality of the blood in von Willebrand's disease correctable by normal plasma.
Nature. 1963 Feb 9;197:601-2 PMID: 14004032

Article Info

Journal

Journal of clinical pathology

Abbr.

J Clin Pathol

ISSN

0021-9746

DOI

10.1136/jcp.17.2.191

Published

1964-03-00

Pages

191-3

Language

English

Region

England

NLM ID

0376601

PMCID

PMC480716

Subset

External Links

PubMed source DOI: 10.1136/jcp.17.2.191 PMC Full Text View journal details

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