PARATHION ACTIVATION BY LIVERS OF AQUATIC AND TERRESTRIAL VERTEBRATES.

Science (New York, N.Y.) ·Vol. 144 ·No. 3614 ·1964-04-03 ·Pages 55-7

POTTER JL, O'BRIEN RD

Abstract

Liver slices from seven terrestrial and six aquatic animals studied "activated" parathion, converting it to paraoxon, a potent anticholinesterase. Although there are similarities between the liver systems which activate parathion and which degrade drugs such as aminopyrine and phenacetin, liver slices of aquatic vertebrates can activate parathion but cannot degrade such drugs.

Keywords

BIRDS CHOLINESTERASE ENZYME INHIBITORS EXPERIMENTAL LAB STUDY FISHES FROGS GUINEA PIGS LIVER FUNCTION METABOLISM MICE PARATHION PHARMACOLOGY RABBITS RATS REPTILES SWINE TOADS

MeSH Terms

Animals Anura Birds Bufonidae Cholinesterase Inhibitors Cholinesterases Enzyme Inhibitors Fishes Guinea Pigs Liver/physiology Metabolism Mice Parathion Pharmacology Rabbits Ranidae Rats Reptiles Research Swine

Chemicals

Cholinesterase Inhibitors Enzyme Inhibitors Parathion Cholinesterases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

POTTER J L

O'BRIEN R D

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.144.3614.55

Published

1964-04-03

Pages

55-7

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.144.3614.55 View journal details

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