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PMID: 14087615 Published · ppublish English Journal Article

COMPLEMENT AS A MEDIATOR OF INFLAMMATION. ENHANCEMENT OF VASCULAR PERMEABILITY BY PURIFIED HUMAN C'1 ESTERASE.

The Journal of experimental medicine ·Vol. 118 ·1963-11-01 ·Pages 681-98

RATNOFF OD, LEPOW IH

Abstract

Purified preparations of the esterase derived from the first component of complement (C'1 esterase) increased vascular permeability in guinea pig skin, an effect inhibited by triprolidine, an antihistaminic agent, but not by soy bean trypsin inhibitor. The permeability-increasing and esterolytic properties of C'1 esterase were inhibited in parallel by the serum inhibitor of C'1 esterase, diisopropylphosphofluoridate and extremes of temperature and pH. Moreover, the permeability-increasing and esterolytic properties evolved in parallel when C'1 esterase was generated from its subcomponents. How C'1 esterase induces changes in vascular permeability remains unexplained, although the possibility that its action is mediated through a histamine-like agent is attractive.

Keywords
ANTIHISTAMINICS BLOOD VESSELS CHROMATOGRAPHY COMPLEMENT ENZYME INHIBITORS ESTERASES EXPERIMENTAL LAB STUDY GUINEA PIGS INFLAMMATION ISOFLUROPHATE MICROSCOPY ELECTRON PERMEABILITY PHARMACOLOGY SKIN
MeSH Terms
Animals Blood Vessels Capillary Permeability Chromatography Complement C1s Complement System Proteins Electrons Enzyme Inhibitors Esterases Guinea Pigs Histamine H1 Antagonists Humans Inflammation Isoflurophate Microscopy Microscopy, Electron Permeability Pharmacology Research Skin Trypsin Inhibitors
Chemicals
Enzyme Inhibitors Histamine H1 Antagonists Trypsin Inhibitors Isoflurophate Complement System Proteins Esterases Complement C1s
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
RATNOFF O D
LEPOW I H
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40 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.118.5.681
Published
1963-11-01
Pages
681-98
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2137679
Subset
OM
External Links
PubMed source DOI: 10.1084/jem.118.5.681 PMC Full Text View journal details
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