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PMID: 14081658 Published · ppublish English Journal Article

EFFECT OF SOME BLOCKING DRUGS ON THE PRESSOR RESPONSE TO PHYSOSTIGMINE IN THE RAT.

British journal of pharmacology and chemotherapy ·Vol. 21 ·1963-10-00 ·Pages 273-84

GOKHALE SD, GULATI OD, JOSHI NY

Abstract

Bretylium and guanethidine blocked the pressor effect of physostigmine and potentiated the responses to adrenaline and noradrenaline on the blood pressure of the rat. Morphine and atropine in small doses blocked the pressor effect of physostigmine without interfering with the actions of adrenaline and noradrenaline. Chlorpromazine in small doses (0.5 to 2.5 mg/kg) blocked the pressor effect of physostigmine and potentiated the responses to noradrenaline whilst those to adrenaline remained unaltered. 3,6-Di(3-diethylaminopropoxy)pyridazine di(methiodide) (Win 4981) blocked the pressor effect of physostigmine and, in its early stages, this block was partially reversed by choline chloride. N-Diethylaminoethyl-N-isopentyl-N'N'-diisopropylurea (P-286), in a dose that reduced the effect of dimethylphenylpiperazinium, had no effect on the pressor response to physostigmine or on the responses to adrenaline and noradrenaline. Hexamethonium, even in large doses (100 mg/kg), only blocked partially the effect of physostigmine while mecamylamine produced a complete block; the responses to adrenaline and noradrenaline were potentiated in both instances.

Keywords
ATROPINE BLOOD PRESSURE BRETYLIUM COMPOUNDS CHLORPROMAZINE CHOLINE EPINEPHRINE EXPERIMENTAL LAB STUDY GUANETHIDINE HEXAMETHONIUM COMPOUNDS MECAMYLAMINE MORPHINE NOREPINEPHRINE PHARMACOLOGY PHYSOSTIGMINE RATS
MeSH Terms
Atropine Blood Pressure Bretylium Compounds Chlorpromazine Choline Epinephrine Guanethidine Hexamethonium Hexamethonium Compounds Mecamylamine Morphine Norepinephrine Pharmacology Physostigmine Rats Research Vasoconstrictor Agents
Chemicals
Bretylium Compounds Hexamethonium Compounds Vasoconstrictor Agents Hexamethonium Mecamylamine Morphine Atropine Physostigmine Choline bretylium Chlorpromazine Norepinephrine Epinephrine Guanethidine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
GOKHALE S D
GULATI O D
JOSHI N Y
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Article Info
Journal
British journal of pharmacology and chemotherapy
Abbr.
Br J Pharmacol Chemother
ISSN
0366-0826
DOI
10.1111/j.1476-5381.1963.tb01526.x
Published
1963-10-00
Pages
273-84
Language
English
Region
England
NLM ID
0154627
PMCID
PMC1703838
Subset
OM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1963.tb01526.x PMC Full Text
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