The contact phase of coagulation in the presence of heparin.
The effect of heparin on the contact phase of coagulation has been investigated by a technique utilizing a solution of toluidine blue in calcium chloride. Heparin in a concentration of 7 units/ml. of plasma does not inhibit contact activation by glass. It is suggested that heparin does not prevent the activation of factor XII (Hageman factor) by glass or the subsequent formation of active factor XI (plasma thromboplastin antecedent).
6 references, click to expand
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The action of thromboplastic substances.J Physiol. 1953 Dec 29;122(3):554-69 PMID: 13118560
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The role of Hageman factor in the initiation of blood coagulation.Br J Haematol. 1959 Apr;5(2):203-11 PMID: 13651548
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Heparin and Christmas facfactor.Nature. 1958 Jun 28;181(4626):1801-2 PMID: 13566150
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Heparin resistance, thromboplastin generation and glass activation.Thromb Diath Haemorrh. 1961 Jul 15;6:144-56 PMID: 13707290
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Initiation of blood coagulation by glass and related surfaces.J Physiol. 1957 Jun 18;137(1):95-109 PMID: 13439587
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The effect of human plasma on the anticoagulant activity of heparin.J Clin Invest. 1950 Apr;29(4):470-4 PMID: 15415449
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