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PMID: 13959516 Published · ppublish English Journal Article

The fine structure of the basement membrane in epidermal tumors.

The Journal of cell biology ·Vol. 15 ·1962-11-00 ·Pages 335-42

FREI JV

Abstract

Epidermal tumors were induced in Swiss female mice by a topical application of 9,10-dimethyl-1,2-benzanthracene solution followed by repeated applications of croton oil solutions. Fourteen benign and malignant tumors were sampled 25 weeks after the treatment had begun, fixed in osmium tetroxide or potassium permanganate, and embedded in Epon. Sections stained with lead hydroxide were examined. In three tumors defects of the epidermal basement membrane were seen. These defects accompanied local invasion of the tumors. The possible mechanisms of the development of this unusual anatomical situation are discussed.

Keywords
BENZANTHRACENES CROTON OIL SKIN NEOPLASMS
MeSH Terms
9,10-Dimethyl-1,2-benzanthracene Animals Basement Membrane Benz(a)Anthracenes Croton Oil Female Mice Neoplasms, Experimental Skin Neoplasms
Chemicals
Benz(a)Anthracenes 9,10-Dimethyl-1,2-benzanthracene Croton Oil benz(a)anthracene
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
FREI J V
References (27)
27 references, click to expand
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.15.2.335
Published
1962-11-00
Pages
335-42
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2106146
Subset
OM
External Links
PubMed source DOI: 10.1083/jcb.15.2.335 PMC Full Text View journal details
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