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PMID: 13939125 Published · ppublish English Journal Article

Electron microscopic study of the ATPase activity of the BAI strain A (myeloblastosis) avian tumor virus.

The Journal of cell biology ·Vol. 15 ·1962-12-00 ·Pages 451-62

NOVIKOFF AB, DE THE G, BEARD D, BEARD JW

Abstract

Thymus glands of chicks with leukemia induced by BAI strain A (myeloblastosis) virus were fixed in cold 4 per cent formaldehyde-sucrose. Frozen sections were incubated in the ATPase medium of Wachstein and Meisel and studied by light microscopy and electron microscopy. The ATPase activity of the virus is localized to the outermost membrane of the virus. The membrane of the blast-like cells of the thymus cortex from which the virus emerges, by budding, also possesses such activity. It appears likely that the outermost membrane of the virus is derived from the plasma membrane of these cells.

Keywords
ADENOSINE TRIPHOSPHATASE AVIAN LEUKOSIS VIRUS
MeSH Terms
Adenosine Triphosphatases Animals Avian Leukosis Virus Birds Cell Division Electrons Leukocytes Microscopy, Electron Neoplasms Oncogenic Viruses Research
Chemicals
Adenosine Triphosphatases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
NOVIKOFF A B
DE THE G
BEARD D
BEARD J W
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21 references, click to expand
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.15.3.451
Published
1962-12-00
Pages
451-62
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2106171
Subset
OM
External Links
PubMed source DOI: 10.1083/jcb.15.3.451 PMC Full Text View journal details
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