Altered immune responsiveness associated with Encephalitozoon cuniculi infection in rabbits.

Infection and immunity ·Vol. 15 ·No. 2 ·1977-02-00 ·Pages 392-5

Cox JC

Abstract

The variation in immune response of two unrelated colonies of laboratory rabbits to high doses of heat-killed Brucella abortus strain 19 was investigated. One was a mixed-breed, multicolored colony in which a high prevalence of encephalitozoonosis had been recorded, whereas the other rabbits were derived from a colony of Dutch-marked specific-pathogen-free rabits. Although considerable variation in the immune response between individual rabbits was noticed at all bleeds, rabbits infected with Encephalitozoon cuniculi showed, on comparison with uninfected rabbits from either colony, a depressed immunoglobulin G response from week 5 of the antigen injection schedule and, from week 8, an elevated immunoglobulin M response.

MeSH Terms

Animals Antibodies, Bacterial/biosynthesis Apicomplexa/immunology Brucella abortus/immunology Immunoglobulin G/biosynthesis Immunoglobulin M/biosynthesis Protozoan Infections/immunology Rabbits Specific Pathogen-Free Organisms Time Factors

Chemicals

Antibodies, Bacterial Immunoglobulin G Immunoglobulin M

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Cox J C

References (16)

16 references, click to expand

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Article Info

Journal

Infection and immunity

Abbr.

Infect Immun

ISSN

0019-9567

DOI

10.1128/iai.15.2.392-395.1977

Published

1977-02-00

Pages

392-5

Language

English

Region

United States

NLM ID

0246127

PMCID

PMC421380

Subset

External Links

PubMed source DOI: 10.1128/iai.15.2.392-395.1977 PMC Full Text View journal details

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Altered immune responsiveness associated with Encephalitozoon cuniculi infection in rabbits.

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