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PMID: 1391987 Published · ppublish English Journal Article

The Nottingham Prognostic Index in primary breast cancer.

Breast cancer research and treatment ·Vol. 22 ·No. 3 ·1992-00-00 ·Pages 207-19

Galea MH, Blamey RW, Elston CE, Ellis IO

Abstract

In 1982 we constructed a prognostic index for patients with primary, operable breast cancer. This index was based on a retrospective analysis of 9 factors in 387 patients. Only 3 of the factors (tumour size, stage of disease, and tumour grade) remained significant on multivariate analysis. The index was subsequently validated in a prospective study of 320 patients. We now present the results of applying this prognostic index to all of the first 1,629 patients in our series of operable breast cancer up to the age of 70. We have used the index to define three subsets of patients with different chances of dying from breast cancer: 1) good prognosis, comprising 29% of patients with 80% 15-year survival; 2) moderate prognosis, 54% of patients with 42% 15-year survival; 3) poor prognosis, 17% of patients with 13% 15-year survival. The 15-year survival of an age-matched female population was 83%.

MeSH Terms
Breast Neoplasms/mortality,pathology Female Humans Lymphatic Metastasis Neoplasm Invasiveness Prognosis Survival Rate
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Galea M H
Nottingham City Hospital, U.K.
Blamey R W
Elston C E
Ellis I O
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Article Info
Journal
Breast cancer research and treatment
Abbr.
Breast Cancer Res Treat
ISSN
0167-6806
DOI
10.1007/BF01840834
Published
1992-00-00
Pages
207-19
Language
English
Region
Netherlands
NLM ID
8111104
Subset
IM
Corrections
CommentIn
PMID: 8267734
External Links
PubMed source DOI: 10.1007/BF01840834 View journal details
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