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PMID: 13905104 Published · ppublish English Journal Article

Effect of adrenaline infusions on the catechol amine content of cat and rat tissues.

British journal of pharmacology and chemotherapy ·Vol. 18 ·1962-02-00 ·Pages 183-9

HARVEY JA, PENNEFATHER JN

Abstract

Infusions of adrenaline failed to produce a significant increase in the adrenaline and noradrenaline content of cat uterus and kidney and of rat uterus and spleen, using normal and reserpine-treated animals. The adrenaline content of extracts of the organs was assayed on the isolated rat uterus, which was stimulated electrically; the noradrenaline content was assayed on the blood pressure of the pithed rat. The tissues studied contained relatively small quantities of adrenaline and this was not decreased by reserpine. Our results show a difference between the stores of adrenaline and noradrenaline in these tissues; the noradrenaline stores are larger, they are depleted by reserpine, and they are increased by an infusion of noradrenaline.

Keywords
CATECHOLAMINES/metabolism EPINEPHRINE/pharmacology RESERPINE/pharmacology
MeSH Terms
Animals Blood Pressure Catecholamines/metabolism Catechols Cats Epinephrine/pharmacology Norepinephrine Rats Reserpine/pharmacology Spleen
Chemicals
Catecholamines Catechols Reserpine Norepinephrine Epinephrine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
HARVEY J A
PENNEFATHER J N
References (12)
12 references, click to expand
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Article Info
Journal
British journal of pharmacology and chemotherapy
Abbr.
Br J Pharmacol Chemother
ISSN
0366-0826
Published
1962-02-00
Pages
183-9
Language
English
Region
England
NLM ID
0154627
PMCID
PMC1482157
Subset
OM
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