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PMID: 1386516 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

A molecular model of MHC class-I-restricted antigen processing.

Immunology today ·Vol. 13 ·No. 5 ·1992-05-00 ·Pages 173-9

Monaco JJ

Abstract

Cells of higher vertebrates have evolved mechanisms that allow a sample of their intracellular contents to be available for surveillance by the immune system. This display of intracellular material is in the form of peptides bound to cell surface major histocompatibility complex (MHC) class I molecules. In this review, John Monaco presents a model of the mechanisms by which this takes place, based on the recent identification of a number of new genes in the MHC.

MeSH Terms
ATP Binding Cassette Transporter, Subfamily B, Member 2 ATP Binding Cassette Transporter, Subfamily B, Member 3 ATP-Binding Cassette Transporters Animals Antigen-Presenting Cells/immunology,metabolism Antigens/immunology,metabolism Biological Transport Carrier Proteins/genetics,metabolism Endopeptidases/metabolism Endoplasmic Reticulum/metabolism Histocompatibility Antigens Class I/genetics,immunology Histocompatibility Antigens Class II/genetics,metabolism Humans Immunologic Surveillance Major Histocompatibility Complex Membrane Proteins/genetics,metabolism Mice Models, Biological Peptide Fragments/immunology,metabolism Rats Recombinant Fusion Proteins/metabolism T-Lymphocytes, Regulatory/immunology
Chemicals
ATP Binding Cassette Transporter, Subfamily B, Member 2 ATP Binding Cassette Transporter, Subfamily B, Member 3 ATP-Binding Cassette Transporters Antigens Carrier Proteins Histocompatibility Antigens Class I Histocompatibility Antigens Class II Membrane Proteins Peptide Fragments Recombinant Fusion Proteins TAP1 protein, human Tap1 protein, mouse Tap1 protein, rat Tap2 protein, mouse Tap2 protein, rat TAP2 protein, human Endopeptidases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Monaco J J
Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0678.
Article Info
Journal
Immunology today
Abbr.
Immunol Today
ISSN
0167-5699
Published
1992-05-00
Pages
173-9
Language
English
Region
England
NLM ID
8008346
Subset
IM
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