Abstract
Cells of higher vertebrates have evolved mechanisms that allow a sample of their intracellular contents to be available for surveillance by the immune system. This display of intracellular material is in the form of peptides bound to cell surface major histocompatibility complex (MHC) class I molecules. In this review, John Monaco presents a model of the mechanisms by which this takes place, based on the recent identification of a number of new genes in the MHC.
MeSH Terms
ATP Binding Cassette Transporter, Subfamily B, Member 2
ATP Binding Cassette Transporter, Subfamily B, Member 3
ATP-Binding Cassette Transporters
Animals
Antigen-Presenting Cells/immunology,metabolism
Antigens/immunology,metabolism
Biological Transport
Carrier Proteins/genetics,metabolism
Endopeptidases/metabolism
Endoplasmic Reticulum/metabolism
Histocompatibility Antigens Class I/genetics,immunology
Histocompatibility Antigens Class II/genetics,metabolism
Humans
Immunologic Surveillance
Major Histocompatibility Complex
Membrane Proteins/genetics,metabolism
Mice
Models, Biological
Peptide Fragments/immunology,metabolism
Rats
Recombinant Fusion Proteins/metabolism
T-Lymphocytes, Regulatory/immunology
Chemicals
ATP Binding Cassette Transporter, Subfamily B, Member 2
ATP Binding Cassette Transporter, Subfamily B, Member 3
ATP-Binding Cassette Transporters
Antigens
Carrier Proteins
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
Membrane Proteins
Peptide Fragments
Recombinant Fusion Proteins
TAP1 protein, human
Tap1 protein, mouse
Tap1 protein, rat
Tap2 protein, mouse
Tap2 protein, rat
TAP2 protein, human
Endopeptidases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Monaco J J
Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0678.