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PMID: 1386267 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

The CREB family of transcription activators.

Current opinion in genetics & development ·Vol. 2 ·No. 2 ·1992-04-00 ·Pages 199-204

Brindle PK, Montminy MR

Abstract

A diverse family of transcription factors bind to the cAMP-response elements found in a variety of mammalian and viral gene promoters. One of the members of this family, CREB, is being intensively studied so as to elucidate the mechanisms by which second messenger signal transduction pathways act to positively and negatively regulate transcription.

MeSH Terms

Amino Acid Sequence Cyclic AMP Response Element-Binding Protein DNA-Binding Proteins/physiology Gene Expression Regulation/physiology Molecular Sequence Data Phosphorylation Signal Transduction/physiology Transcription Factors/physiology Transcription, Genetic/physiology

Chemicals

Cyclic AMP Response Element-Binding Protein DNA-Binding Proteins Transcription Factors

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Brindle P K

Salk Institute for Biological Science, La Jolla, California.

Montminy M R

Article Info

Journal

Current opinion in genetics & development

Abbr.

Curr Opin Genet Dev

ISSN

0959-437X

DOI

10.1016/s0959-437x(05)80274-6

Published

1992-04-00

Pages

199-204

Language

English

Region

England

NLM ID

9111375

Subset

Grants

NIGMS NIH HHS · GM14562 · United States

NIGMS NIH HHS · GM37828 · United States

External Links

PubMed source DOI: 10.1016/s0959-437x(05)80274-6 View journal details

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