Calcium-binding proteins in the nervous system.

Trends in neurosciences ·Vol. 15 ·No. 8 ·1992-08-00 ·Pages 303-8

Baimbridge KG, Celio MR, Rogers JH

Abstract

Among the many calcium-binding proteins in the nervous system, parvalbumin, calbindin-D28K and calretinin are particularly striking in their abundance and in the specificity of their distribution. They can be found in different subsets of neurons in many brain regions. Although it is not yet known whether they play a 'triggering' role like calmodulin, or merely act as buffers to modulate cytosolic calcium transients, they are valuable markers of neuronal subpopulations for anatomical and developmental studies.

MeSH Terms

Action Potentials Amino Acid Sequence Animals Biomarkers Brain Chemistry Calcium/metabolism Calcium Channels/metabolism Calcium-Binding Proteins/metabolism,physiology Consensus Sequence Ion Channel Gating Mammals/metabolism Models, Molecular Molecular Sequence Data Multigene Family Nerve Degeneration Nerve Tissue Proteins/metabolism,physiology Neurons/metabolism Neurotransmitter Agents/metabolism Retina/metabolism Species Specificity

Chemicals

Biomarkers Calcium Channels Calcium-Binding Proteins Nerve Tissue Proteins Neurotransmitter Agents Calcium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Baimbridge K G

Physiology Dept, University of British Columbia, Vancouver, Canada.

Celio M R

Rogers J H

Article Info

Journal

Trends in neurosciences

Abbr.

Trends Neurosci

ISSN

0166-2236

DOI

10.1016/0166-2236(92)90081-i

Published

1992-08-00

Pages

303-8

Language

English

Region

England

NLM ID

7808616

Subset

External Links

PubMed source DOI: 10.1016/0166-2236(92)90081-i View journal details

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