The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia.

British journal of pharmacology ·Vol. 106 ·No. 4 ·1992-08-00 ·Pages 766-7

Buisson A, Plotkine M, Boulu RG

Abstract

Recent data showed that glutamate toxicity in primary cortical cultures is mediated by nitric oxide. In order to investigate the effect of inhibition of NO synthase on focal cerebral ischaemia in rats, we studied the histological consequences of a middle cerebral artery (MCA) occlusion after post-operative treatment with NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase. We found a significant reduction of cortical (-43%) and striatal (-25%) necrotic volumes induced by MCA occlusion, indicating that NO synthesis plays an important role in the neurotoxic cascade leading to neuronal damage after focal cerebral ischaemia in rats.

MeSH Terms

Amino Acid Oxidoreductases/antagonists & inhibitors Anesthesia Animals Arginine/analogs & derivatives,pharmacology Blood Pressure/drug effects Brain Ischemia/drug therapy Disease Models, Animal Male NG-Nitroarginine Methyl Ester Necrosis/drug therapy Nitric Oxide Synthase Rats Rats, Inbred Strains

Chemicals

Arginine Nitric Oxide Synthase Amino Acid Oxidoreductases NG-Nitroarginine Methyl Ester

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Buisson A

Laboratoire de Pharmacologie, Faculté des Sciences Pharmaceutiques et Biologiques, Université René Descartes, Paris, France.

Plotkine M

Boulu R G

References (9)

9 references, click to expand

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.
Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6368-71 PMID: 1648740
Nitric oxide as a neuronal messenger.
Trends Pharmacol Sci. 1991 Apr;12(4):125-8 PMID: 1712138
Methods for antagonizing glutamate neurotoxicity.
Cerebrovasc Brain Metab Rev. 1990 Summer;2(2):105-47 PMID: 2201346
The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat.
Ann Neurol. 1988 Oct;24(4):543-51 PMID: 2853604
The double-edged role of nitric oxide in brain function and superoxide-mediated injury.
J Dev Physiol. 1991 Jan;15(1):53-9 PMID: 1678755
Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo.
Br J Pharmacol. 1990 Nov;101(3):746-52 PMID: 1706208
Glutamate, nitric oxide and cell-cell signalling in the nervous system.
Trends Neurosci. 1991 Feb;14(2):60-7 PMID: 1708538
Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse.
Eur J Pharmacol. 1991 Nov 12;204(3):339-40 PMID: 1773832
Continuous nimodipine treatment attenuates cortical infarction in rats subjected to 24 hours of focal cerebral ischemia.
J Cereb Blood Flow Metab. 1990 Jan;10(1):89-96 PMID: 2298839

Article Info

Journal

British journal of pharmacology

Abbr.

Br J Pharmacol

ISSN

0007-1188

DOI

10.1111/j.1476-5381.1992.tb14410.x

Published

1992-08-00

Pages

766-7

Language

English

Region

England

NLM ID

7502536

PMCID

PMC1907643

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1992.tb14410.x PMC Full Text View journal details

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The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia.

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