| GeneLibs

题目:: Cells and mediators involved in immunoglobulin synthesis by human circulating mononuclear cells. IV. B cells synthesize but do not secrete immunoglobulins because of a defect in the non-T non-B (null) cells.
作者:: Richter(M),Jodouin(C A),Steele(D)
状态:: 发布时间1992-10-20 , 更新时间 2006-11-15
期刊:: J Allergy Clin Immunol
摘要:: Null cells (non-T and non-B lymphocytes) have previously been demonstrated to be obligatory participants for immunoglobulin synthesis and secretion by normal B cells in culture. Normal null cells have been demonstrated to secrete a factor, human immunoglobulin synthesis/secretion-facilitating factor (HISFF), which can replace the null cells in the culture. In this investigation, the B cells of an 8-month-old male infant and a 46-year-old male adult who presented with a humoral (antibody) immunodeficiency syndrome synthesized immunoglobulin but did not secrete immunoglobulin after culture with pokeweed mitogen and autologous T cells, monocytes, and null cells. In contrast, the patients' B cells synthesized and secreted immunoglobulin after the addition of allogeneic normal null cells or HISFF to the cultures. The same results were obtained with the cells of the infant and the adult patient tested at monthly intervals for 4 months. The results demonstrate that the patients' T cells, B cells, and monocytes functioned normally and that only the patients' null cells were defective. These findings provide an explanation for the absence of immunoglobulin in the circulation of "non(immunoglobulin)secretors," although they possess normal numbers of circulating immunoglobulin-synthesizing B cells. The defect is in the null cell and not in the B cell and consists of the inability of the null cell to secrete HISFF that facilitates the synthesis and secretion of immunoglobulin by the B cell.
语言:: eng
DOI:

文献库文献相关信息

DataTable pData

联系方式

微信公众号

文献库 文献相关信息

DataTable pData

联系方式

微信公众号

文献库文献相关信息