Sensory neuropathy associated with monoclonal immunoglobulin M to GD1b ganglioside.

Annals of neurology ·Vol. 31 ·No. 6 ·1992-06-00 ·Pages 683-5

Daune GC, Farrer RG, Dalakas MC, Quarles RH

Abstract

A 67-year-old woman with a sensory polyneuropathy was shown to have a serum monoclonal immunoglobulin M lambda antibody with a titer of 1:10,000 toward GD1b ganglioside. The immunoglobulin M also reacted with some other gangliosides containing disialosyl groups such as GD2, GD3, and GQ1b, but it did not react with GM1, LM1, or GD1a. The principal reactive ganglioside in human cauda equina was GD1b.

MeSH Terms

Aged Antibodies, Monoclonal/immunology Autoantibodies/immunology Autoimmune Diseases/etiology,immunology Cauda Equina/immunology Epitopes/immunology Extremities Female Gangliosides/immunology Humans Hypesthesia/etiology,immunology Immunoglobulin M/immunology Monoclonal Gammopathy of Undetermined Significance/complications,immunology Paresthesia/etiology,immunology Peripheral Nerves/immunology

Chemicals

Antibodies, Monoclonal Autoantibodies Epitopes Gangliosides Immunoglobulin M ganglioside, GD1b

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Daune G C

Myelin and Brain Development Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.

Farrer R G

Dalakas M C

Quarles R H

Article Info

Journal

Annals of neurology

Abbr.

Ann Neurol

ISSN

0364-5134

DOI

10.1002/ana.410310621

Published

1992-06-00

Pages

683-5

Language

English

Region

United States

NLM ID

7707449

Subset

External Links

PubMed source DOI: 10.1002/ana.410310621 View journal details

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Sensory neuropathy associated with monoclonal immunoglobulin M to GD1b ganglioside.

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