Induced synthesis of liver microsomal enzymes which metabolize foreign compounds.

Science (New York, N.Y.) ·Vol. 130 ·No. 3387 ·1959-11-27 ·Pages 1478-9

CONNEY AH, GILLETTE JR, INSCOE JK, TRAMS ER, POSNER HS

Abstract

The administration of 3,4-benzpyrene to rats markedly increases the activities of certain liver microsomal enzymes which metabolize foreign compounds. Evidence based on studies of enzyme induction is presented which suggests the presence in liver microsomes of several enzymes which can catalyze the same type of reaction.

Keywords

ENZYMES LIVER

MeSH Terms

Animals Enzyme Induction Enzymes Liver Male Microsomes, Liver Rats

Chemicals

Enzymes

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

CONNEY A H

GILLETTE J R

INSCOE J K

TRAMS E R

POSNER H S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.130.3387.1478

Published

1959-11-27

Pages

1478-9

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.130.3387.1478 View journal details

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Induced synthesis of liver microsomal enzymes which metabolize foreign compounds.

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