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PMID: 1380898 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Hyaluronan and cell locomotion.

Cancer metastasis reviews ·Vol. 11 ·No. 1 ·1992-03-00 ·Pages 21-30

Turley EA

Abstract

Hyaluronan (HA), a glycosaminoglycan, has long been implicated in cell locomotion. We have shown that HA production regulates the locomotion of H-ras-transformed cells. This autocrine motility mechanism is mediated by a novel HA receptor termed RHAMM, an acronym for Receptor for HA Mediated Motility. HA:RHAMM interactions regulate directional locomotion of tumor cells and result in enhanced protein tyrosine phosphorylation that may be a critical messenger mechanism for initiation of locomotion.

Related Genes
H-ras
MeSH Terms
Animals Cell Movement/physiology Genes, ras/physiology Humans Hyaluronan Receptors Hyaluronic Acid/physiology Neoplasms/physiopathology Rats Receptors, Cell Surface/physiology Wound Healing/physiology
Chemicals
Hyaluronan Receptors Receptors, Cell Surface Hyaluronic Acid
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Turley E A
Manitoba Institute of Cell Biology, Winnipeg, Canada.
References (46)
46 references, click to expand
  1. The tandemly repeated sequences of cartilage link protein contain the sites for interaction with hyaluronic acid.
    J Cell Biol. 1987 Nov;105(5):2403-8 PMID: 2445761
  2. Characterization and purification of the hyaluronan-receptor on liver endothelial cells.
    Biochim Biophys Acta. 1991 May 30;1078(1):12-8 PMID: 1710929
  3. Hyaluronic acid (Sperm Select) improves retention of sperm motility and velocity in normospermic and oligospermic specimens.
    Fertil Steril. 1990 Dec;54(6):1127-34 PMID: 1700958
  4. Increased mRNA expression of a laminin-binding protein in human colon carcinoma: complete sequence of a full-length cDNA encoding the protein.
    Proc Natl Acad Sci U S A. 1988 Sep;85(17):6394-8 PMID: 2970639
  5. Hyaluronan as a propellant for epithelial movement: the development of semicircular canals in the inner ear of Xenopus.
    Development. 1991 Jun;112(2):541-50 PMID: 1794322
  6. Repair of chronic tympanic membrane perforations using applications of hyaluronan or rice paper prostheses.
    ORL J Otorhinolaryngol Relat Spec. 1991;53(1):37-40 PMID: 2008293
  7. Hyaluronic acid stimulates protein kinase activity in intact cells and in an isolated protein complex.
    J Biol Chem. 1989 May 25;264(15):8951-5 PMID: 2722809
  8. Molecular composition and origin of substrate-attached material from normal and virus-transformed cells.
    J Supramol Struct. 1976;5(2):239-55 PMID: 1003970
  9. Developmental role of hyaluronate.
    Connect Tissue Res. 1982;10(1):93-100 PMID: 6216071
  10. Complete primary structure of the rat cartilage proteoglycan core protein deduced from cDNA clones.
    J Biol Chem. 1987 Dec 25;262(36):17757-67 PMID: 3693370
  11. The biological activity of hyaluron sulfuric acid.
    Acta Physiol Scand. 1951 Aug 25;23(2-3):168-78 PMID: 14868516
  12. Early cell motility changes associated with an increase in metastatic ability in rat prostatic cancer cells transfected with the v-Harvey-ras oncogene.
    Cancer Res. 1988 Nov 1;48(21):6050-3 PMID: 3048653
  13. Proteoglycans and cell adhesion. Their putative role during tumorigenesis.
    Cancer Metastasis Rev. 1984;3(4):325-39 PMID: 6083829
  14. Evidence for a precursor of the high-affinity metastasis-associated murine laminin receptor.
    Biochemistry. 1989 Sep 5;28(18):7476-86 PMID: 2531008
  15. Developmentally regulated changes in extracellular matrix in endothelial and smooth muscle cells in the ductus arteriosus may be related to intimal proliferation.
    Lab Invest. 1991 Feb;64(2):187-99 PMID: 1997732
  16. Isolation of streptococcal hyaluronate synthase.
    Biochem J. 1986 May 1;235(3):887-9 PMID: 3092808
  17. The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells.
    EMBO J. 1991 Feb;10(2):343-8 PMID: 1991450
  18. Structural analyses on the matrical organization of glycosaminoglycans in developing endocardial cushions.
    Dev Biol. 1978 Feb;62(2):292-316 PMID: 564303
  19. Hyaluronan and its binding proteins, the hyaladherins.
    Curr Opin Cell Biol. 1990 Oct;2(5):839-44 PMID: 1707285
  20. Bifunctional properties of lectins: lectins redefined.
    Trends Biochem Sci. 1988 Dec;13(12 ):480-2 PMID: 2855286
  21. The histochemical specificity of Streptomyces hyaluronidase and chondroitinase ABC.
    Histochem J. 1978 Sep;10(5):529-47 PMID: 80394
  22. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells.
    Cell. 1991 Apr 5;65(1):13-24 PMID: 1707342
  23. Mechanism of action of the migration stimulating factor produced by fetal and cancer patient fibroblasts: effect on hyaluronic and synthesis.
    In Vitro Cell Dev Biol. 1989 Aug;25(8):737-46 PMID: 2768134
  24. Inducible cellular transformation by a metallothionein-ras hybrid oncogene leads to natural killer cell susceptibility.
    Nature. 1986 Jun 19-25;321(6072):782-4 PMID: 3520342
  25. Hyaluronan and a cell-associated hyaluronan binding protein regulate the locomotion of ras-transformed cells.
    J Cell Biol. 1991 Mar;112(5):1041-7 PMID: 1705559
  26. A hyaluronate binding protein transiently codistributes with p21k-ras in cultured cell lines.
    Exp Cell Res. 1989 Jun;182(2):340-8 PMID: 2470603
  27. Accumulation of hyaluronic acid in the alveolar interstitial tissue in bleomycin-induced alveolitis.
    Am Rev Respir Dis. 1989 Mar;139(3):759-62 PMID: 2466429
  28. Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility.
    J Cell Biol. 1992 Jun;117(6):1343-50 PMID: 1376732
  29. The primary structure of link protein from rat chondrosarcoma proteoglycan aggregate.
    J Biol Chem. 1986 Mar 15;261(8):3519-35 PMID: 2419334
  30. Fibronectin, hyaluronan, and a hyaluronan binding protein contribute to increased ductus arteriosus smooth muscle cell migration.
    Dev Biol. 1991 Feb;143(2):235-47 PMID: 1703972
  31. Receptors for hyaluronate on the surface of parent and virus-transformed cell lines: binding and aggregation studies.
    Exp Cell Res. 1981 Feb;131(2):419-23 PMID: 7202543
  32. Regulation of granulocyte function by hyaluronic acid. In vitro and in vivo effects on phagocytosis, locomotion, and metabolism.
    J Clin Invest. 1980 Aug;66(2):298-305 PMID: 7400316
  33. Characterization and purification from human brain of a hyaluronic acid-binding glycoprotein, hyaluronectin.
    J Neurochem. 1981 Mar;36(3):855-9 PMID: 6162916
  34. Effects of hyaluronic acid on cardiac cushion tissue cells in collagen matrix cultures.
    Tex Rep Biol Med. 1979;39:271-85 PMID: 553314
  35. Proteoglycans: structure, function, and role in neoplasia.
    Lab Invest. 1985 Oct;53(4):373-96 PMID: 2413275
  36. Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis.
    Microvasc Res. 1977 Jul;14(1):53-65 PMID: 895546
  37. Hyaluronic acid stimulates neutrophil function in vitro and in vivo. A review of experimental results and a presentation of a preliminary clinical trial.
    Scand J Infect Dis Suppl. 1980;Suppl 24:54-7 PMID: 7010564
  38. Isolation and partial characterization of a glial hyaluronate-binding protein.
    J Biol Chem. 1989 Apr 5;264(10):5981-7 PMID: 2466833
  39. Studies in vitro on the uptake and degradation of sodium hyaluronate in rat liver endothelial cells.
    Biochem J. 1984 Nov 1;223(3):617-26 PMID: 6508733
  40. A fibroblast chondroitin sulfate proteoglycan core protein contains lectin-like and growth factor-like sequences.
    J Biol Chem. 1987 Sep 25;262(27):13120-5 PMID: 2820964
  41. Early changes in lung tissue hyaluronan (hyaluronic acid) and hyaluronidase in bleomycin-induced alveolitis in hamsters.
    Am Rev Respir Dis. 1991 Feb;143(2):284-8 PMID: 1703735
  42. Characterization of hyaluronate binding proteins isolated from 3T3 and murine sarcoma virus transformed 3T3 cells.
    Biochemistry. 1987 Jun 2;26(11):2997-3005 PMID: 2440472
  43. Studies in fetal wound healing. IV. Hyaluronic acid-stimulating activity distinguishes fetal wound fluid from adult wound fluid.
    Ann Surg. 1989 Nov;210(5):667-72 PMID: 2818035
  44. Hyaluronic acid synthesis and turnover by myotubes in culture.
    Dev Biol. 1979 Dec;73(2):322-37 PMID: 499671
  45. Affinity and distribution of surface and intracellular hyaluronic acid receptors in isolated rat liver endothelial cells.
    J Biol Chem. 1988 Nov 15;263(32):16661-8 PMID: 2460454
  46. Monoclonal antibody to chick embryo hyaluronan-binding protein: changes in distribution of binding protein during early brain development.
    Dev Biol. 1991 Jul;146(1):186-97 PMID: 1711984
Article Info
Journal
Cancer metastasis reviews
Abbr.
Cancer Metastasis Rev
ISSN
0167-7659
DOI
10.1007/BF00047600
Published
1992-03-00
Pages
21-30
Language
English
Region
Netherlands
NLM ID
8605731
Subset
IM
Grants
NCI NIH HHS · CA 51540 01A1 · United States
External Links
PubMed source DOI: 10.1007/BF00047600 View journal details
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