Home LiteratureArticle Details
PMID: 1378508 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

The interaction of two groups of murine genes determines the persistence of Theiler's virus in the central nervous system.

Journal of virology ·Vol. 66 ·No. 8 ·1992-08-00 ·Pages 4698-704

Bureau JF, Montagutelli X, Lefebvre S, Guénet JL, Pla M, Brahic M

Abstract

Theiler's murine encephalomyelitis virus is responsible for a chronic inflammatory demyelinating disease of the central nervous system of the mouse. The disease is associated with persistent viral infection of the spinal cord. Some strains of mice are susceptible to viral infection, and other strains are resistant. The effect of the genetic background of the host on viral persistence has not been thoroughly investigated. We studied the amount of viral RNA in the spinal cords of 17 inbred strains of mice and their F1 crosses with the SJL/J strain and observed a large degree of variability among strains. The pattern of viral persistence among mouse strains could be explained by the interaction of two loci. One locus is localized in the H-2D region of the major histocompatibility complex, whereas the other locus is outside this complex and is not linked to the Tcrb locus on chromosome 6.

MeSH Terms
Animals Brain/microbiology Chromosome Mapping Crosses, Genetic DNA/analysis,genetics DNA, Viral/analysis,genetics Genetic Predisposition to Disease H-2 Antigens/genetics Major Histocompatibility Complex Maus Elberfeld virus/pathogenicity,physiology Mice Mice, Inbred Strains/genetics Polymerase Chain Reaction RNA/analysis,genetics RNA, Viral/analysis,genetics Species Specificity Spinal Cord/microbiology Virulence
Chemicals
DNA, Viral H-2 Antigens RNA, Viral RNA DNA
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Bureau J F
Unité des Virus Lents, UA 1157, Centre National de la Recherche Scientifique, Institut Pasteur, Paris, France.
Montagutelli X
Lefebvre S
Guénet J L
Pla M
Brahic M
References (39)
39 references, click to expand
  1. Hierarchy of effects of the MHC and T cell receptor beta-chain genes in susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease.
    J Immunol. 1991 Dec 15;147(12):4322-6 PMID: 1836484
  2. Successful therapy of Theiler's virus-induced demyelination (DA strain) with monoclonal anti-Lyt-2 antibody.
    J Immunol. 1988 May 1;140(9):2950-5 PMID: 2966203
  3. A rapid method for genotyping mice for T cell receptor V beta a and V beta b haplotypes by PCR analysis of whole blood.
    J Immunol Methods. 1990 Dec 31;135(1-2):209-12 PMID: 1980283
  4. The 5' noncoding sequences from a less virulent Theiler's virus dramatically attenuate GDVII neurovirulence.
    J Virol. 1991 Aug;65(8):4370-7 PMID: 2072455
  5. Genetic mapping of the ability of Theiler's virus to persist and demyelinate.
    J Virol. 1990 Sep;64(9):4252-7 PMID: 2166814
  6. Demyelination induced by Theiler's virus: influence of the H-2 haplotype.
    J Immunol. 1985 Sep;135(3):2145-8 PMID: 2991380
  7. Quantitation, with a new assay, of Theiler's virus capsid protein in the central nervous system of mice.
    J Virol. 1986 Nov;60(2):558-63 PMID: 3021989
  8. Partial suppression of Theiler's virus-induced demyelination in vivo by administration of monoclonal antibodies to immune-response gene products (Ia antigens).
    Neurology. 1986 Jul;36(7):964-70 PMID: 3487048
  9. Mechanism of Theiler's virus-induced demyelination in nude mice.
    Lab Invest. 1986 May;54(5):515-22 PMID: 3517486
  10. Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in mice is influenced by the H-2D region: correlation with TEMV-specific delayed-type hypersensitivity.
    J Immunol. 1985 Aug;135(2):1408-14 PMID: 3925009
  11. Theiler's virus antigen detected in mouse spinal cord 2 1/2 years after infection.
    Neurology. 1984 Aug;34(8):1117-9 PMID: 6087205
  12. Persistent infection of oligodendrocytes in Theiler's virus-induced encephalomyelitis.
    Ann Neurol. 1983 Apr;13(4):426-33 PMID: 6340596
  13. Genetic analysis of susceptibility to Theiler's virus-induced demyelinating disease in mice.
    J Immunol. 1984 Apr;132(4):1821-5 PMID: 6699403
  14. Identification of a locus on mouse chromosome 3 involved in differential susceptibility to Theiler's murine encephalomyelitis virus-induced demyelinating disease.
    J Virol. 1990 Feb;64(2):686-90 PMID: 2296080
  15. Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus.
    Crit Rev Immunol. 1987;7(4):325-65 PMID: 2827957
  16. Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease. II. Survey of host immune responses and central nervous system virus titers in inbred mouse strains.
    Microb Pathog. 1987 Nov;3(5):327-37 PMID: 2849024
  17. Susceptibility to Theiler's virus-induced demyelination. Mapping of the gene within the H-2D region.
    J Exp Med. 1986 Mar 1;163(3):620-31 PMID: 3005466
  18. Immunoglobulins and complement in demyelination induced in mice by Theiler's virus.
    J Immunol. 1988 Feb 1;140(3):800-6 PMID: 3339243
  19. Theiler's virus RNA and protein synthesis in the central nervous system of demyelinating mice.
    Virology. 1985 Jul 15;144(1):290-4 PMID: 3840619
  20. Demyelinating lesions due to Theiler's virus are associated with ongoing central nervous system infection.
    J Virol. 1986 Mar;57(3):992-7 PMID: 3951022
  21. The effect of short-term and chronic immunosuppression on Theiler's virus demyelination.
    J Neuroimmunol. 1982 Jun;2(3-4):223-34 PMID: 6282927
  22. DA strain of Theiler's murine encephalomyelitis virus induces demyelination in nude mice.
    Ann Neurol. 1984 May;15(5):494-9 PMID: 6732198
  23. Contrasting effects of immunosuppression on Theiler's virus infection in mice.
    Infect Immun. 1977 Mar;15(3):903-9 PMID: 192679
  24. Recurrent demyelination in chronic central nervous system infection produced by Theiler's murine encephalomyelitis virus.
    J Neurol Sci. 1979 Aug;42(3):391-405 PMID: 512673
  25. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
    Biochemistry. 1979 Nov 27;18(24):5294-9 PMID: 518835
  26. Cytotoxic T cells isolated from the central nervous systems of mice infected with Theiler's virus.
    J Virol. 1991 Dec;65(12):6612-20 PMID: 1658365
  27. Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. IV. Identification of an immunodominant T cell determinant on the N-terminal end of the VP2 capsid protein in susceptible SJL/J mice.
    J Immunol. 1991 Apr 1;146(7):2401-8 PMID: 1706400
  28. Theiler's virus infection induces a specific cytotoxic T lymphocyte response.
    Cell Immunol. 1991 Dec;138(2):341-8 PMID: 1934074
  29. Genetic determinants of the demyelinating disease caused by Theiler's virus.
    Microb Pathog. 1991 Aug;11(2):77-84 PMID: 1961111
  30. Theiler's virus-induced demyelination: prevention by immunosuppression.
    Science. 1976 Apr 2;192(4234):62-4 PMID: 176726
  31. Primary demyelination in Theiler's virus infection. An ultrastructural study.
    Lab Invest. 1975 Dec;33(6):626-37 PMID: 1202282
  32. Restricted virus replication in the spinal cords of nude mice infected with a Theiler's virus variant.
    J Virol. 1991 Feb;65(2):1023-30 PMID: 1987366
  33. Expression of human HLA-B27 transgene alters susceptibility to murine Theiler's virus-induced demyelination.
    J Immunol. 1991 Apr 15;146(8):2596-602 PMID: 2016520
  34. Monocytes/macrophages isolated from the mouse central nervous system contain infectious Theiler's murine encephalomyelitis virus (TMEV).
    Virology. 1990 May;176(1):244-54 PMID: 2158691
  35. Major histocompatibility complex-conferred resistance to Theiler's virus-induced demyelinating disease is inherited as a dominant trait in B10 congenic mice.
    J Virol. 1990 Nov;64(11):5570-6 PMID: 2214025
  36. Two-locus linkage analysis using recombinant inbred strains and Bayes' theorem.
    Genetics. 1990 Sep;126(1):277-84 PMID: 2227386
  37. Characterization of B lymphocytes present in the demyelinating lesions induced by Theiler's virus.
    J Immunol. 1989 Aug 1;143(3):984-8 PMID: 2545781
  38. Identification of Theiler's virus infected cells in the central nervous system of the mouse during demyelinating disease.
    Microb Pathog. 1987 Nov;3(5):319-26 PMID: 2849023
  39. In situ analysis of proteolipid protein gene transcripts during persistent Theiler's virus infection.
    J Histochem Cytochem. 1991 Oct;39(10):1305-9 PMID: 1940303
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.66.8.4698-4704.1992
Published
1992-08-00
Pages
4698-704
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC241295
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.66.8.4698-4704.1992 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2