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PMID: 1377517 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Immune surveillance against Epstein-Barr virus.

Seminars in immunology ·Vol. 4 ·No. 2 ·1992-04-00 ·Pages 97-104

Moss DJ, Burrows SR, Khanna R, Misko IS, Sculley TB

Abstract

Following primary infection, EBV retains a life-long latent association with B lymphocytes and a permissive association with stratified epithelium in the oropharynx. This review presents a model for the host-virus relationships in healthy virus carriers, a relationship which, if perturbed, may result in EBV-associated disease. Cytotoxic T cells that recognise virally-determined epitopes on infected cells are the major effector arm and control the persistant infection. A strategy for developing a vaccine to EBV is discussed.

MeSH Terms

Amino Acid Sequence Antigens, Viral/biosynthesis,immunology B-Lymphocytes/immunology,microbiology Carrier State/immunology,microbiology Epithelium/microbiology Epitopes/immunology Gene Expression Regulation, Viral Herpesviridae Infections/immunology,microbiology Herpesvirus 4, Human/immunology,physiology Humans Immune Tolerance Immunologic Surveillance Infectious Mononucleosis/immunology,microbiology Molecular Sequence Data Neoplasms/immunology,microbiology T-Lymphocytes, Cytotoxic/immunology Viral Proteins/biosynthesis,immunology Viral Vaccines/immunology Virus Replication

Chemicals

Antigens, Viral Epitopes Viral Proteins Viral Vaccines

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Moss D J

Queensland Institute of Medical Research, Herston, Brisbane, Australia.

Burrows S R

Khanna R

Misko I S

Sculley T B

Article Info

Journal

Seminars in immunology

Abbr.

Semin Immunol

ISSN

1044-5323

Published

1992-04-00

Pages

97-104

Language

English

Region

England

NLM ID

9009458

Subset

Grants

NCI NIH HHS · 1 R01 CA 52250-01 · United States

External Links

PubMed source View journal details

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Immune surveillance against Epstein-Barr virus.

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