A study of potential histidine decarboxylase inhibitors.

British journal of pharmacology and chemotherapy ·Vol. 15 ·1960-12-00 ·Pages 552-6

MACKAY D, SHEPHERD DM

Abstract

A series of compounds has been examined for ability to inhibit histidine decarboxylase. Histidine analogues having substituents in the imidazole ring showed a wide variation in potency, but these were all much less active than alpha-methyldopa [beta-(3,4-dihydroxyphenyl)-alpha-methylalanine], the most potent known inhibitor of histidine decarboxylase. Some tentative conclusions are drawn regarding the relationship between chemical structure and inhibitory activity.

Keywords

DESMOLASES/antagonists IMIDAZOLES/pharmacology

MeSH Terms

Aminoisobutyric Acids Histidine Histidine Decarboxylase Imidazoles/pharmacology Lyases/antagonists & inhibitors Methyldopa

Chemicals

Aminoisobutyric Acids Imidazoles 2-aminoisobutyric acid Histidine Methyldopa imidazole Lyases Histidine Decarboxylase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

MACKAY D

SHEPHERD D M

References (4)

4 references, click to expand

Inhibition of dihydroxy-phenylalanine decarboxylase by derivatives of phenylalanine.
Arch Biochem Biophys. 1954 Aug;51(2):444-56 PMID: 13189588
Studies on mammalian histidine decarboxylase.
Br J Pharmacol Chemother. 1956 Jun;11(2):119-27 PMID: 13329325
A place for histamine in normal physiology.
Lancet. 1960 Jan 9;1(7115):67-71 PMID: 14408416
[The effects of hydrazine and guanylhydrazone derivatives on the activity of monoamine oxidase, diamine oxidase, DOPA decarboxylase and histidine decarboxylase].
Klin Wochenschr. 1955 Jun 15;33(23-24):562-7 PMID: 14392887

Article Info

Journal

British journal of pharmacology and chemotherapy

Abbr.

Br J Pharmacol Chemother

ISSN

0366-0826

DOI

10.1111/j.1476-5381.1960.tb00279.x

Published

1960-12-00

Pages

552-6

Language

English

Region

England

NLM ID

0154627

PMCID

PMC1482398

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1960.tb00279.x PMC Full Text

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A study of potential histidine decarboxylase inhibitors.

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