The inhibition by morphine of the action of smooth muscle stimulants on the guinea-pig intestine.

British journal of pharmacology and chemotherapy ·Vol. 15 ·1960-09-00 ·Pages 425-31

LEWIS GP

Abstract

Morphine and related analgesics depress the responses of the isolated guinea-pig ileum to nervous stimulation and to drugs which act by stimulating the nervous structures of the intestinal wall. The present experiments show that these analgesics also depress the responses to smooth muscle stimulants which act directly on the smooth muscle fibres.

Keywords

MORPHINE/pharmacology MUSCLES/physiology

MeSH Terms

Analgesics Central Nervous System Stimulants Guinea Pigs Ileum Intestines Morphine/pharmacology Muscle, Smooth Muscles/physiology

Chemicals

Analgesics Central Nervous System Stimulants Morphine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

LEWIS G P

References (7)

7 references, click to expand

Mechanism of the contraction of the longitudinal muscle of the isolated guinea-pig ileum, caused by raising the pressure in the lumen.
J Physiol. 1955 Jul 28;129(1):18-9P PMID: 13252607
A pharmacological analysis of the mode of action of serotonin (5-hydroxytryptamine) upon the guinea-pig ileum.
Br J Pharmacol Chemother. 1953 Dec;8(4):378-88 PMID: 13115625
An antagonism of 5-hydroxytryptamine by atropine.
J Physiol. 1953 Aug;121(2):54P-55P PMID: 13085362
The paralysing action of morphine on the guinea-pig ileum.
Br J Pharmacol Chemother. 1955 Dec;10(4):456-61 PMID: 13276604
Classification of intestinomotor drugs by means of type D botulinum toxin.
J Physiol. 1955 Mar 28;127(3):449-78 PMID: 14368542
Effects of ganglion-blocking substances on the small intestine.
J Physiol. 1951 May;113(4):483-505 PMID: 14851253
[Morphinlike analgesics and intestinal motions. I. Spasmolysis and peristalsis].
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1952;215(5-6):460-8 PMID: 12977240

Article Info

Journal

British journal of pharmacology and chemotherapy

Abbr.

Br J Pharmacol Chemother

ISSN

0366-0826

DOI

10.1111/j.1476-5381.1960.tb01267.x

Published

1960-09-00

Pages

425-31

Language

English

Region

England

NLM ID

0154627

PMCID

PMC1481856

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1960.tb01267.x PMC Full Text

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The inhibition by morphine of the action of smooth muscle stimulants on the guinea-pig intestine.

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