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PMID: 1374584 Published · ppublish English Case Reports Journal Article Research Support, Non-U.S. Gov't

Infiltration of helper/inducer T lymphocytes heralds central nervous system damage in human T-cell leukemia virus infection.

The American journal of pathology ·Vol. 140 ·No. 5 ·1992-05-00 ·Pages 1003-8

Iwasaki Y, Ohara Y, Kobayashi I, Akizuki S

Abstract

Cellular infiltrates in new and old lesions in two cases of human T-cell leukemia virus associated myelopathy (HAM) were analyzed with anti-CD3 antibody and OPD4 antibody recognizing CD4 + CD45RO + T lymphocytes. A subset of CD4 lymphocytes with helper/inducer function and labeled with OPD4 constitutes up to 65% of CD3 cells in new lesions in the pons and the cervical cord. In contrast, nonhelper cells and macrophages were dominant in long-standing spinal cord lesions of these HAM cases and inflammatory lesions in two cases of Japanese encephalitis. Thus, unlike in viral infections, the central nervous system (CNS) tissue damage associated with human T-cell leukemia virus (HTLV-1) infection appeared to be heralded by the infiltration of helper/inducer T cells.

MeSH Terms

Antibodies, Monoclonal Antigens, CD/analysis Antigens, Differentiation, T-Lymphocyte/analysis CD3 Complex Central Nervous System Diseases/pathology Glial Fibrillary Acidic Protein/metabolism Humans Immunohistochemistry/methods Male Middle Aged Paraparesis, Tropical Spastic/immunology,metabolism,pathology Receptors, Antigen, T-Cell/analysis Staining and Labeling T-Lymphocytes, Helper-Inducer/physiology

Chemicals

Antibodies, Monoclonal Antigens, CD Antigens, Differentiation, T-Lymphocyte CD3 Complex Glial Fibrillary Acidic Protein Receptors, Antigen, T-Cell

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Iwasaki Y

Department of Neurological Sciences, Tohoku University School of Medicine, Sendai, Japan.

Ohara Y

Kobayashi I

Akizuki S

References (25)

25 references, click to expand

Analysis of factors of relevance to rapid clinical progression in HTLV-I-associated myelopathy.
J Neurol Sci. 1991 Sep;105(1):61-6 PMID: 1795171
Two distinct antigen systems in human B lymphocytes: identification of cell surface and intracellular antigens using monoclonal antibodies.
Clin Exp Immunol. 1984 Oct;58(1):183-92 PMID: 6332692
Increases in helper inducer T cells and activated T cells in HTLV-I-associated myelopathy.
Ann Neurol. 1989 Aug;26(2):257-62 PMID: 2528320
Tropical spastic paraparesis and human T cell lymphotropic virus type 1 in the United Kingdom.
Brain. 1989 Aug;112 ( Pt 4):1057-90 PMID: 2775992
Isolation of an HTLV-1-like retrovirus from patients with tropical spastic paraparesis.
Nature. 1988 Feb 11;331(6156):540-3 PMID: 2829028
Necropsy findings in HTLV-I associated myelopathy.
Lancet. 1987 Jan 17;1(8525):156-7 PMID: 2879986
Pathological and immunological observations on tropical spastic paraparesis in patients from Jamaica.
Ann Neurol. 1988;23 Suppl:S156-60 PMID: 2894808
Loss of functional suppression is linked to decreases in circulating suppressor inducer (CD4+ 2H4+) T cells in multiple sclerosis.
Ann Neurol. 1988 Aug;24(2):185-91 PMID: 2972249
Leukoencephalopathy in HTLV-I-associated myelopathy: MRI and EEG data.
J Neurol Sci. 1988 Nov;87(2-3):221-32 PMID: 3210034
Multiple sclerosis. Distribution of T cells, T cell subsets and Ia-positive macrophages in lesions of different ages.
J Neuroimmunol. 1983 Jun;4(3):201-21 PMID: 6222066
Monoclonal antibody OPD4 is reactive with CD45RO, but differs from UCHL1 by the absence of monocyte reactivity.
Am J Pathol. 1991 Oct;139(4):725-9 PMID: 1833980
In vivo cellular tropism of human T-cell leukemia virus type 1.
J Virol. 1990 Nov;64(11):5682-7 PMID: 1976827
Pathology of chronic myelopathy associated with HTLV-I infection (HAM/TSP).
J Neurol Sci. 1990 Apr;96(1):103-23 PMID: 2351985
A novel monoclonal antibody (OPD4) recognizing a helper/inducer T cell subset. Its application to paraffin-embedded tissues.
Am J Pathol. 1989 Jun;134(6):1339-46 PMID: 2527008
Detection of T cells in paraffin wax embedded tissue using antibodies against a peptide sequence from the CD3 antigen.
J Clin Pathol. 1989 Nov;42(11):1194-200 PMID: 2531171
[Paraplegia associated with HTLV-1 virus].
Rev Neurol (Paris). 1989;145(4):260-6 PMID: 2660218
Tropical spastic paraparesis: a model of virus-induced, cytotoxic T-cell-mediated demyelination?
Ann Neurol. 1989 Oct;26(4):523-30 PMID: 2817828
HTLV-I associated myelopathy, a new clinical entity.
Lancet. 1986 May 3;1(8488):1031-2 PMID: 2871307
Isolation of HTLV-I from cerebrospinal fluid of a patient with myelopathy.
Lancet. 1986 Aug 16;2(8503):397-8 PMID: 2874393
Antibody to human T-lymphotropic virus type 1 in West-Indian-born UK residents with spastic paraparesis.
Lancet. 1987 Feb 21;1(8530):415-6 PMID: 2880217
The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions.
J Immunol. 1988 Apr 1;140(7):2210-4 PMID: 2965183
Fluctuations of CD4+ T-cell subsets in remitting-relapsing multiple sclerosis.
Ann Neurol. 1988 Aug;24(2):192-9 PMID: 2972250
Immunohistochemical demonstration of viral antigens in Japanese encephalitis.
Acta Neuropathol. 1986;70(1):79-81 PMID: 3014801
Identification of the normal microglial population in human and rodent nervous tissue using lectin-histochemistry.
Neuropathol Appl Neurobiol. 1988 May-Jun;14(3):221-7 PMID: 3405394
Nationwide survey of HTLV-I-associated myelopathy in Japan: association with blood transfusion.
Ann Neurol. 1990 Jul;28(1):50-6 PMID: 2375633

Article Info

Journal

The American journal of pathology

Abbr.

Am J Pathol

ISSN

0002-9440

Published

1992-05-00

Pages

1003-8

Language

English

Region

United States

NLM ID

0370502

PMCID

PMC1886515

Subset

External Links

PubMed source PMC Full Text View journal details

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Infiltration of helper/inducer T lymphocytes heralds central nervous system damage in human T-cell leukemia virus infection.

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