Effect of actinomycin D on cellular nucleic acid synthesis and virus production.

Science (New York, N.Y.) ·Vol. 134 ·No. 3478 ·1961-08-25 ·Pages 556-7

REICH E, FRANKLIN RM, SHATKIN AJ, TATUM EL

Abstract

Actinomycin D inhibits the synthesis of ribonucleic acid in L cells and the yield of vaccinia virus containing deoxyribonucleic acid, but it does not inhibit cellular deoxyribonucleic acid synthesis or the multiplication of Mengo virus containing ribonucleic acid. These observations serve to distinguish the replication of viral ribonucleic from ribonucleic acid synthesis which is controlled by viral or cellular deoxyribonucleic acid.

Keywords

ACTINOMYCIN/pharmacology CYTOLOGY NUCLEIC ACIDS/metabolism VACCINIA/virology

MeSH Terms

Cell Biology DNA DNA Replication Dactinomycin/pharmacology Nucleic Acids/metabolism RNA Vaccinia/virology Vaccinia virus

Chemicals

Nucleic Acids Dactinomycin RNA DNA

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

REICH E

FRANKLIN R M

SHATKIN A J

TATUM E L

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.134.3478.556

Published

1961-08-25

Pages

556-7

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.134.3478.556 View journal details

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Effect of actinomycin D on cellular nucleic acid synthesis and virus production.

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