The formation of an isoprenaline-like substance from adrenaline.

British journal of pharmacology and chemotherapy ·Vol. 16 ·1961-02-00 ·Pages 108-15

EAKINS KE, LOCKETT MF

Abstract

Intravenous injections of adrenaline, but not those of noradrenaline, caused the appearance of a substance which resembled isoprenaline in R(F) value and pharmacological activity in blood withdrawn from the lower abdominal aortae of chloralosed cats rested after acute adrenalectomy and induction of lasting block in autonomic ganglia with hexamethonium. The formation of the isoprenaline-like compound was prevented by pretreatment with pyrogallol but not by pretreatment with reserpine, cocaine, phentolamine, dibenamine, harmaline, or iproniazid. The liver proved a main site of the origin of this isoprenaline-like substance.

Keywords

EPINEPHRINE/metabolism

MeSH Terms

Animals Cats Cocaine Epinephrine/metabolism Hexamethonium Iproniazid Isoproterenol Liver Norepinephrine Reserpine

Chemicals

Hexamethonium Reserpine Iproniazid Cocaine Isoproterenol Norepinephrine Epinephrine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

EAKINS K E

LOCKETT M F

References (8)

8 references, click to expand

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Article Info

Journal

British journal of pharmacology and chemotherapy

Abbr.

Br J Pharmacol Chemother

ISSN

0366-0826

DOI

10.1111/j.1476-5381.1961.tb00303.x

Published

1961-02-00

Pages

108-15

Language

English

Region

England

NLM ID

0154627

PMCID

PMC1482014

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1961.tb00303.x PMC Full Text

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The formation of an isoprenaline-like substance from adrenaline.

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