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PMID: 1370810 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Dinucleotide (CA/GT) repeat polymorphism in intron 17B of the cystic fibrosis transmembrane conductance regulator (CFTR) gene.

Human genetics ·Vol. 88 ·No. 3 ·1992-01-00 ·Pages 356

Morral N, Girbau E, Zielenski J, Nunes V, Casals T, Tsui LC, Estivill X

Abstract

We describe a polymorphic microsatellite (IVS17BCA) in intron 17B of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. It consists of an 11 to 20 CA/GT dinucleotide repeat, located 424 bp from exon 17B.

MeSH Terms
Alleles Base Sequence Cystic Fibrosis/genetics Cystic Fibrosis Transmembrane Conductance Regulator Electrophoresis, Polyacrylamide Gel Humans Introns Membrane Proteins/genetics Molecular Sequence Data Nucleotides/genetics Oligonucleotides/genetics Polymerase Chain Reaction Polymorphism, Genetic Repetitive Sequences, Nucleic Acid
Chemicals
CFTR protein, human Membrane Proteins Nucleotides Oligonucleotides Cystic Fibrosis Transmembrane Conductance Regulator
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Morral N
Molecular Genetics Department, Hospital Duran i Reynals, L'Hospitalet de Llobregat, Barcelona, Spain.
Girbau E
Zielenski J
Nunes V
Casals T
Tsui L C
Estivill X
References (3)
3 references, click to expand
  1. Genomic DNA sequence of the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
    Genomics. 1991 May;10(1):214-28 PMID: 1710598
  2. CA/GT microsatellite alleles within the cystic fibrosis transmembrane conductance regulator (CFTR) gene are not generated by unequal crossingover.
    Genomics. 1991 Jul;10(3):692-8 PMID: 1716244
  3. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.
    Science. 1988 Jan 29;239(4839):487-91 PMID: 2448875
Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00197276
Published
1992-01-00
Pages
356
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00197276 View journal details
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