Molecular genetics of sex determination in C. elegans.

Trends in genetics : TIG ·Vol. 8 ·No. 5 ·1992-05-00 ·Pages 164-8

Kuwabara PE, Kimble J

Abstract

Sexual fate in the nematode Caenorhabditis elegans is controlled by a group of genetically well-characterized genes. Several of these sex-determining genes have now been analysed at the molecular level. Transcriptional regulation is likely to control both commitment to a single sexual fate and maintenance of that decision; in addition, intercellular signalling appears to coordinate the sexual fates of cells throughout the animal to adopt a single sexual fate.

Related Genes

fem-1 fem-2 fem-3 fog-1 her-1 sdc-1 tra-1 tra-2 tra-3 xol-1

MeSH Terms

Animals Caenorhabditis elegans/genetics Cell Communication Disorders of Sex Development/genetics Gene Expression Regulation, Developmental Genes, Helminth Helminth Proteins/physiology Models, Genetic Sex Chromosomes Sex Determination Analysis Signal Transduction Transcription Factors/physiology Transcription, Genetic Zinc Fingers

Chemicals

Helminth Proteins Transcription Factors

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kuwabara P E

Department of Biochemistry, College of Agriculture and Life Sciences, University of Wisconsin-Madison 53706, USA.

Kimble J

Article Info

Journal

Trends in genetics : TIG

Abbr.

Trends Genet

ISSN

0168-9525

DOI

10.1016/0168-9525(92)90218-s

Published

1992-05-00

Pages

164-8

Language

English

Region

England

NLM ID

8507085

Subset

External Links

PubMed source DOI: 10.1016/0168-9525(92)90218-s View journal details

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Molecular genetics of sex determination in C. elegans.

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