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PMID: 13675772 Published · ppublish English Journal Article

Inhibition of O-methyltransferase by catechol and sensitization to epinephrine.

Science (New York, N.Y.) ·Vol. 130 ·No. 3373 ·1959-08-21 ·Pages 453-4

BACQ ZM, GOSSELIN L, DRESSE A, RENSON J

Abstract

Catechol at equimolecular concentration inhibits the inactivation of adrenaline by O-methyltransferase in vitro about 50 percent. The inhibition is probably responsible for the sensitization of smooth muscles to epinephrine by various ortho di- or triphenols.

Keywords
EPINEPHRINE/physiology PYROCATECHOL/effects TRANSFERASES
MeSH Terms
Catechols/pharmacology Epinephrine/physiology Humans Learning Methyltransferases Transferases
Chemicals
Catechols Transferases Methyltransferases catechol Epinephrine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
BACQ Z M
GOSSELIN L
DRESSE A
RENSON J
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.130.3373.453
Published
1959-08-21
Pages
453-4
Language
English
Region
United States
NLM ID
0404511
Subset
OM
External Links
PubMed source DOI: 10.1126/science.130.3373.453 View journal details
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