The renal lesions of electrolyte imbalance. II. The combined effect on renal architecture of phosphate loading and potassium depletion.

The Journal of experimental medicine ·Vol. 110 ·No. 2 ·1959-08-01 ·Pages 161-8

HOLLIDAY MA, WINTERS RW, WELT LG, MACDOWELL M, OLIVER J

Abstract

Potassium depletion in rats augments the specific renal lesions of phosphate loading. Since it has been shown that phosphate loading increases the specific cardiac lesions of potassium deficiency (12), it is concluded that the similar types of electrolyte imbalance (potassium depletion-phosphate load) act conversely in the two organs.

Keywords

KIDNEYS/pathology PHOSPHATES/effects POTASSIUM/deficiency

MeSH Terms

Animals Kidney/pathology Phosphates/pharmacology Potassium Potassium Compounds Potassium Deficiency Rats

Chemicals

Phosphates Potassium Compounds potassium phosphate Potassium

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

HOLLIDAY M A

WINTERS R W

WELT L G

MACDOWELL M

OLIVER J

References (10)

10 references, click to expand

Kidney changes in hypokalemic alkalosis in the rat.
J Lab Clin Med. 1954 May;43(5):802-14 PMID: 13163581
Kidney glutaminase and carbonic anhydrase activity and tissue electrolyte composition in potassium-deficient dogs.
Am J Physiol. 1955 Dec;183(3):395-400 PMID: 13283051
Potassium-losing renal disease; renal and metabolic observations on a patient sustaining renal wastage of potassium.
Q J Med. 1956 Jan;25(97):21-52 PMID: 13323241
Aminoaciduria in relation to deficiency diseases and kidney function.
J Am Med Assoc. 1957 Aug 3;164(14):1571-7 PMID: 13448910
Defect in the renal tubular reabsorption of water associated with potassium depletion in rats.
Am J Physiol. 1957 Jun;189(3):557-63 PMID: 13458384
The renal lesions of electrolyte imbalance. I. The structural alterations in potassium-depleted rats.
J Exp Med. 1957 Oct 1;106(4):563-74 PMID: 13475614
Provocation and prevention of potassium deficiency by various ions.
Proc Soc Exp Biol Med. 1958 Jul;98(3):580-3 PMID: 13567778
The pathogenesis of acute renal failure associated with traumatic and toxic injury; renal ischemia, nephrotoxic damage and the ischemic episode.
J Clin Invest. 1951 Dec;30(12:1):1307-439 PMID: 14897900
Effects of electrolyte depletion and acid-base disturbance on muscle cations.
Am J Physiol. 1951 Dec;167(3):665-75 PMID: 14903092
RENAL DAMAGE FOLLOWING THE INGESTION OF A DIET CONTAINING AN EXCESS OF INORGANIC PHOSPHATE.
J Exp Med. 1935 Feb 28;61(3):319-34 PMID: 19870361

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.110.2.161

Published

1959-08-01

Pages

161-8

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2136987

Subset

External Links

PubMed source DOI: 10.1084/jem.110.2.161 PMC Full Text View journal details

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The renal lesions of electrolyte imbalance. II. The combined effect on renal architecture of phosphate loading and potassium depletion.

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