Products of the major histocompatibility complex and their relationship to the immune response.

Nature ·Vol. 264 ·No. 5582 ·1976-11-11 ·Pages 145-52

Munro A, Bright S

Abstract

The genes of the major histocompatibility complex were first known for the part they played in transplant rejection. Recently, however, it has become clear that the products of that region have an important part to play in the control of the immune response, through their effects both on cooperative and on aggressive interactions between cells. It is now possible to guess at the mechanisms which may underly the association of some major histocompatibility antigens with disease.

MeSH Terms

Alleles Animals Antibody Formation Autoimmune Diseases/immunology B-Lymphocytes/immunology Chromosome Mapping Complement System Proteins Cytotoxicity Tests, Immunologic Gene Frequency Genes Genetic Linkage HLA Antigens Histocompatibility Antigens/classification Humans Hypersensitivity, Immediate/immunology Immunity, Cellular Isoantigens Leukemia, Lymphoid/immunology Lymphocyte Culture Test, Mixed Membrane Proteins/immunology Mice Models, Biological Spondylitis, Ankylosing/immunology T-Lymphocytes/immunology Whites beta 2-Microglobulin/immunology

Chemicals

HLA Antigens Histocompatibility Antigens Isoantigens Membrane Proteins beta 2-Microglobulin Complement System Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Munro A

Bright S

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/264145a0

Published

1976-11-11

Pages

145-52

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/264145a0 View journal details

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Products of the major histocompatibility complex and their relationship to the immune response.

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