A microbath.
A microbath, with a volume of less than 50 cubic millimetres, for testing the effects of drugs on small pieces of smooth muscle, is described. Drugs are applied automatically in any desired order and the record of their effects is amplified electrically. In this apparatus the response of small pieces of rat uterus to drugs is apt to be nearly all-or-none. Contractions of the muscle from a single ring of guinea-pig trachea were recorded. A fall of pH was found to reduce the effect of 5-hydroxytryptamine on this muscle while leaving the effects of tryptamine and acetylcholine unchanged.
5 references, click to expand
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The use of some molluscan hearts for the estimation of 5-hydroxytryptamine.Br J Pharmacol Chemother. 1955 Dec;10(4):474-83 PMID: 13276607
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The estimation of adrenaline and allied substances in blood.J Physiol. 1949 Jun 15;108(4):467-81 PMID: 16991878
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The effect on the intestine of the substance liberated by adrenergic nerves in a rabbit's ear.J Physiol. 1939 Jun 14;96(1):104-8 PMID: 16995111
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Assay of histamine on the isolated guinea-pig intestine by the method of superfusion.Br J Pharmacol Chemother. 1954 Sep;9(3):360-6 PMID: 13199257
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A method of conducting a biological assay on a preparation giving repeated graded responses illustrated by the estimation of histamine.J Physiol. 1942 Jun 2;101(1):115-30 PMID: 16991544
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