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PMID: 1360022 Published · ppublish English Journal Article

Memory and naive CD4+ lymphocytes in multiple sclerosis.

Journal of neurology ·Vol. 239 ·No. 8 ·1992-10-00 ·Pages 437-40

Porrini AM, Gambi D, Malatesta G

Abstract

Helper-inducer (CD29+CD4+) and suppressor-inducer (CD45RACD4+) T-cells have been recently renamed as memory and naive T-cells, respectively. We measured cells expressing these phenotypes in peripheral blood of 46 definite multiple sclerosis (MS) patients [32 relapsing-remitting (RR-MS), 14 secondary progressive (P-MS)] and controls. CD25+ (interleukin-2-receptor-positive) cells were also evaluated in the same groups of patients. RR-MS patients showed increased levels of CD29+CD4+ and CD25+ cells compared with controls. This finding was more evident in RR-MS patients during the attack than during the stable phase of the disease. In P-MS patients we found a reduction of CD45+CD4+ cells compared with either RR-MS patients or control subjects. Our results show that RR-MS and P-MS are characterized by two different T-cell subpopulations. This finding supports the hypothesis that during the evolution from RR-MS and P-MS changes occur in the immunological status of the patients.

MeSH Terms
Adult Antigens, CD/blood CD4-Positive T-Lymphocytes/pathology Female Flow Cytometry Humans Immunophenotyping Leukocyte Common Antigens/blood Leukocyte Count Male Middle Aged Multiple Sclerosis/immunology,pathology Receptors, Interleukin-2/analysis T-Lymphocyte Subsets/pathology
Chemicals
Antigens, CD Receptors, Interleukin-2 Leukocyte Common Antigens
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Porrini A M
Department of Clinical Neurology, University of Chieti, Italy.
Gambi D
Malatesta G
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31 references, click to expand
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Article Info
Journal
Journal of neurology
Abbr.
J Neurol
ISSN
0340-5354
DOI
10.1007/BF00856808
Published
1992-10-00
Pages
437-40
Language
English
Region
Germany
NLM ID
0423161
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00856808 View journal details
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