Home LiteratureArticle Details
PMID: 1354266 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Phylogenetic analysis of the thiolase family. Implications for the evolutionary origin of peroxisomes.

Journal of molecular evolution ·Vol. 35 ·No. 2 ·1992-08-00 ·Pages 147-55

Igual JC, González-Bosch C, Dopazo J, Pérez-Ortín JE

Abstract

The thiolase family is a widespread group of proteins present in prokaryotes and three cellular compartments of eukaryotes. This fact makes this family interesting in order to study the evolutionary process of eukaryotes. Using the sequence of peroxisomal thiolase from Saccharomyces cerevisiae recently obtained by us and the other known thiolase sequences, a phylogenetic analysis has been carried out. It shows that all these proteins derived from a primitive enzyme, present in the common ancestor of eubacteria and eukaryotes, which evolved into different specialized thiolases confined to various cell compartments. The evolutionary tree obtained is compatible with the endosymbiotic theory for the origin of peroxisomes.

MeSH Terms
Acetyl-CoA C-Acetyltransferase/classification,genetics Amino Acid Sequence Biological Evolution Microbodies/enzymology Molecular Sequence Data Phylogeny Saccharomyces cerevisiae/enzymology,genetics Sequence Alignment Symbiosis
Chemicals
Acetyl-CoA C-Acetyltransferase
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Igual J C
Departamento de Bioquímica y Biología Molecular, Universitat de València, Spain.
González-Bosch C
Dopazo J
Pérez-Ortín J E
References (49)
49 references, click to expand
  1. Construction of phylogenetic trees.
    Science. 1967 Jan 20;155(3760):279-84 PMID: 5334057
  2. Cloning, sequencing and analysis of the yeast S. uvarum ERG10 gene encoding acetoacetyl CoA thiolase.
    Curr Genet. 1988 Jun;13(6):471-8 PMID: 2900076
  3. Molecular cloning and deduced amino acid sequence of nonspecific lipid transfer protein (sterol carrier protein 2) of rat liver: a higher molecular mass (60 kDa) protein contains the primary sequence of nonspecific lipid transfer protein as its C-terminal part.
    Proc Natl Acad Sci U S A. 1991 May 15;88(10):4338-42 PMID: 2034675
  4. The simultaneous symbiotic origin of mitochondria, chloroplasts, and microbodies.
    Ann N Y Acad Sci. 1987;503:55-71 PMID: 3304084
  5. Complete cDNA sequence of human foetal liver peroxisomal 3-oxoacyl-CoA thiolase.
    Nucleic Acids Res. 1989 May 11;17(9):3588 PMID: 2726492
  6. Isolation, nucleotide sequence analysis, and disruption of the MDH2 gene from Saccharomyces cerevisiae: evidence for three isozymes of yeast malate dehydrogenase.
    Mol Cell Biol. 1991 Jan;11(1):370-80 PMID: 1986231
  7. The oxoacyl-coenzyme A thiolases of animal tissues.
    Biochem J. 1973 Apr;132(4):717-30 PMID: 4721607
  8. Structural analysis of cDNA for rat peroxisomal 3-ketoacyl-CoA thiolase.
    J Biol Chem. 1987 Jun 15;262(17):8151-8 PMID: 3036803
  9. The neighbor-joining method: a new method for reconstructing phylogenetic trees.
    Mol Biol Evol. 1987 Jul;4(4):406-25 PMID: 3447015
  10. Nucleotide sequence of the fadA gene. Primary structure of 3-ketoacyl-coenzyme A thiolase from Escherichia coli and the structural organization of the fadAB operon.
    J Biol Chem. 1990 Jun 25;265(18):10424-9 PMID: 2191949
  11. Synonymous codon usage in Saccharomyces cerevisiae.
    Yeast. 1991 Oct;7(7):657-78 PMID: 1776357
  12. Rat liver peroxisomes catalyze the initial step in cholesterol synthesis. The condensation of acetyl-CoA units into acetoacetyl-CoA.
    J Biol Chem. 1990 Apr 5;265(10):5731-5 PMID: 1969406
  13. Five different enzymatic activities are associated with the multienzyme complex of fatty acid oxidation from Escherichia coli.
    J Bacteriol. 1979 Jan;137(1):469-73 PMID: 368024
  14. Biogenesis of peroxisomes.
    Annu Rev Cell Biol. 1985;1:489-530 PMID: 3916321
  15. Fast and sensitive multiple sequence alignments on a microcomputer.
    Comput Appl Biosci. 1989 Apr;5(2):151-3 PMID: 2720464
  16. Purification of the multienzyme complex for fatty acid oxidation from Pseudomonas fragi and reconstitution of the fatty acid oxidation system.
    J Biochem. 1990 Feb;107(2):184-9 PMID: 2361950
  17. Purification of glyoxysomal acetyl-CoA acyltransferase.
    Hoppe Seylers Z Physiol Chem. 1980 Apr;361(4):537-42 PMID: 7380394
  18. Sequence of the Saccharomyces cerevisiae CTA1 gene and amino acid sequence of catalase A derived from it.
    Eur J Biochem. 1988 Sep 1;176(1):159-63 PMID: 3046940
  19. Rat peroxisomal 3-ketoacyl-CoA thiolase gene. Occurrence of two closely related but differentially regulated genes.
    J Biol Chem. 1990 Mar 15;265(8):4600-6 PMID: 2307679
  20. CONFIDENCE LIMITS ON PHYLOGENIES: AN APPROACH USING THE BOOTSTRAP.
    Evolution. 1985 Jul;39(4):783-791 PMID: 28561359
  21. RNA-mediated transfer of the gene coxII from the mitochondrion to the nucleus during flowering plant evolution.
    Cell. 1991 Aug 9;66(3):473-81 PMID: 1714355
  22. Occurrence and possible roles of acetoacetyl-CoA thiolase and 3-ketoacyl-CoA thiolase in peroxisomes of an n-alkane-grown yeast, Candida tropicalis.
    FEBS Lett. 1988 Feb 29;229(1):215-8 PMID: 2894324
  23. Cloning and sequence determination of cDNA encoding a second rat liver peroxisomal 3-ketoacyl-CoA thiolase.
    Gene. 1990 Jul 16;91(2):193-9 PMID: 2210380
  24. Nucleotide sequence of human peroxisomal 3-oxoacyl-CoA thiolase.
    Nucleic Acids Res. 1988 Nov 11;16(21):10369 PMID: 3194209
  25. A new glucose-repressible gene identified from the analysis of chromatin structure in deletion mutants of yeast SUC2 locus.
    Yeast. 1991 May-Jun;7(4):379-89 PMID: 1872029
  26. Poly-beta-hydroxybutyrate biosynthesis in Alcaligenes eutrophus H16. Characterization of the genes encoding beta-ketothiolase and acetoacetyl-CoA reductase.
    J Biol Chem. 1989 Sep 15;264(26):15293-7 PMID: 2670935
  27. Properties of peroxisomal 3-ketoacyl-coA thiolase from rat liver.
    J Biochem. 1981 Aug;90(2):511-9 PMID: 6117552
  28. Identification of the cDNA clone which encodes the 58-kDa protein containing the amino acid sequence of rat liver non-specific lipid-transfer protein (sterol-carrier protein 2). Homology with rat peroxisomal and mitochondrial 3-oxoacyl-CoA thiolases.
    Eur J Biochem. 1991 Oct 1;201(1):233-9 PMID: 1915369
  29. The structure of the multienzyme complex of fatty acid oxidation from Escherichia coli.
    J Biol Chem. 1981 Apr 25;256(8):3894-9 PMID: 7012144
  30. Mechanistic studies on beta-ketoacyl thiolase from Zoogloea ramigera: identification of the active-site nucleophile as Cys89, its mutation to Ser89, and kinetic and thermodynamic characterization of wild-type and mutant enzymes.
    Biochemistry. 1989 Jul 11;28(14):5735-42 PMID: 2775734
  31. DISTANCE METHODS FOR INFERRING PHYLOGENIES: A JUSTIFICATION.
    Evolution. 1984 Jan;38(1):16-24 PMID: 28556064
  32. Purification and properties of a pig heart thiolase with broad chain length specificity and comparison of thiolases from pig heart and Escherichia coli.
    J Biol Chem. 1978 Mar 25;253(6):1827-31 PMID: 344310
  33. Endosymbiotic origin and codon bias of the nuclear gene for chloroplast glyceraldehyde-3-phosphate dehydrogenase from maize.
    J Mol Evol. 1987;26(4):320-8 PMID: 3131533
  34. Molecular and catalytic properties of cytosolic acetoacetyl coenzyme A thiolase from avian liver.
    J Biol Chem. 1973 Apr 10;248(7):2275-84 PMID: 4698219
  35. Molecular cloning and sequence of the complementary DNA encoding human mitochondrial acetoacetyl-coenzyme A thiolase and study of the variant enzymes in cultured fibroblasts from patients with 3-ketothiolase deficiency.
    J Clin Invest. 1990 Dec;86(6):2086-92 PMID: 1979337
  36. Molecular cloning and nucleotide sequence of cDNA encoding the entire precursor of rat mitochondrial acetoacetyl-CoA thiolase.
    J Biochem. 1989 Aug;106(2):197-204 PMID: 2478525
  37. Molecular and catalytic properties of the acetoacetyl-coenzyme A thiolase of Escherichia coli.
    Arch Biochem Biophys. 1976 Sep;176(1):159-70 PMID: 9904
  38. Biosynthetic thiolase from Zoogloea ramigera. III. Isolation and characterization of the structural gene.
    J Biol Chem. 1987 Jan 5;262(1):97-102 PMID: 2878929
  39. Mitochondrial and nonmitochondrial citrate synthases in Saccharomyces cerevisiae are encoded by distinct homologous genes.
    Mol Cell Biol. 1986 Dec;6(12):4509-15 PMID: 3540614
  40. The active site cysteines of thiolase.
    Eur J Biochem. 1970 Nov;16(3):492-8 PMID: 5477295
  41. Escape of DNA from mitochondria to the nucleus in Saccharomyces cerevisiae.
    Nature. 1990 Jul 26;346(6282):376-9 PMID: 2165219
  42. cDNA-derived amino acid sequence of rat mitochondrial 3-oxoacyl-CoA thiolase with no transient presequence: structural relationship with peroxisomal isozyme.
    EMBO J. 1987 May;6(5):1361-6 PMID: 3038520
  43. Microbodies in the living cell.
    Sci Am. 1983 May;248(5):74-84 PMID: 6407106
  44. The presence of a new 3-oxoacyl-CoA thiolase in rat liver peroxisomes.
    Eur J Biochem. 1980 Feb;103(3):589-96 PMID: 6766863
  45. Two forms of acetoacetyl coenzyme A thiolase in yeast. II. Intracellular location and relationship to growth.
    J Biol Chem. 1971 Jul 25;246(14):4424-30 PMID: 5571830
  46. Comparative enzymology of beta-oxidation.
    Biochem Soc Trans. 1988 Jun;16(3):418-20 PMID: 3053289
  47. Peroxisome biogenesis revisited.
    Biochim Biophys Acta. 1989 Jun 1;1008(1):1-13 PMID: 2655706
  48. Peroxisomal acetoacetyl-CoA thiolase and 3-ketoacyl-CoA thiolase from an n-alkane-utilizing yeast, Candida tropicalis: purification and characterization.
    J Biochem. 1989 Sep;106(3):474-8 PMID: 2575092
  49. Relative efficiencies of the maximum parsimony and distance-matrix methods in obtaining the correct phylogenetic tree.
    Mol Biol Evol. 1988 May;5(3):298-311 PMID: 3386530
Article Info
Journal
Journal of molecular evolution
Abbr.
J Mol Evol
ISSN
0022-2844
DOI
10.1007/BF00183226
Published
1992-08-00
Pages
147-55
Language
English
Region
Germany
NLM ID
0360051
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00183226 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2