Formation of histamine in the kidney of the dog.

British journal of pharmacology and chemotherapy ·Vol. 13 ·No. 1 ·1958-03-00 ·Pages 89-90

LINDELL SE, SCHAYER RW

Abstract

In dogs [(14)C]L-histidine was given in a steady infusion into one renal artery while urine was collected from both kidneys separately. The urine from the infused kidney contained considerably more [(14)C]histamine than did the urine from the other kidney. The difference between the kidneys in the amounts of [(14)C]histamine appearing in the urine was considered to be due to formation of histamine from histidine in the injected kidney. It is concluded that histamine formed in the kidney may contribute to the urinary histamine.

Keywords

HISTAMINE/metabolism KIDNEYS/metabolism

MeSH Terms

Animals Biochemical Phenomena Body Fluids Dogs Histamine/metabolism Histidine Humans Kidney/metabolism Renal Artery

Chemicals

Histidine Histamine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

LINDELL S E

SCHAYER R W

References (3)

3 references, click to expand

The effect of intravenous infusions of histamine on the urinary histamine and on gastric secretion in man.
Br J Pharmacol Chemother. 1954 Mar;9(1):62-7 PMID: 13149778
The metabolism of alpha-C14-histidine in the intact rat. II. Radioactive excretion products in urine.
J Biol Chem. 1956 Sep;222(1):159-69 PMID: 13366989
Catheterization of the renal arteries in dogs and cats.
Acta Physiol Scand. 1957 Apr 10;39(1):73-82 PMID: 13424332

Article Info

Journal

British journal of pharmacology and chemotherapy

Abbr.

Br J Pharmacol Chemother

ISSN

0366-0826

DOI

10.1111/j.1476-5381.1958.tb00196.x

Published

1958-03-00

Pages

89-90

Language

English

Region

England

NLM ID

0154627

PMCID

PMC1481684

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1958.tb00196.x PMC Full Text

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Formation of histamine in the kidney of the dog.

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