Irreversible hemorrhagic shock in germfree rats.
Evidence has been provided that a state of irreversible hemorrhagic shock can be induced in a bacteria-free environment in rats reared under germfree conditions. The response to bleeding, the duration of the hypotensive episode and the pathological changes were the same in the germfree and in normal stock rats. The findings are interpreted as evidence opposed to the concept that bacteria or bacterial products are implicated, as primary factors, in the pathogenicity of shock.
9 references, click to expand
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Germfree research: a basic study in host-contaminant relationship. III. Morphologic characterization of germfree life.Bull N Y Acad Med. 1955 Mar;31(3):239-42 PMID: 13230770
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Factors associated with protection against experimental shock.Anesthesiology. 1956 Mar;17(2):265-76 PMID: 13302839
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Host resistance to bacteria in hemorrhagic shock. VI. Effect of endotoxin on antibacterial defense.Proc Soc Exp Biol Med. 1956 Aug-Sep;92(4):662-7 PMID: 13370490
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The relationship between the vascular manifestations of shock produced by endotoxin, trauma, and hemorrhage. II. The possible role of the reticulo-endothelial system in resistance to each type of shock.J Exp Med. 1957 Sep 1;106(3):403-14 PMID: 13463250
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Germfree research: a basic study in host-contaminant relationship. II. Serologic observations in germfree animals.Bull N Y Acad Med. 1955 Mar;31(3):236-9 PMID: 13230769
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Serum properdin levels in hemorrhagic shock.Proc Soc Exp Biol Med. 1955 Jun;89(2):223-5 PMID: 14395272
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Bacterial action in development of irreversibility to transfusion in hemorrhagic shock in the dog.Am J Physiol. 1954 Dec;179(3):523-31 PMID: 13228623
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Bacterial factor in experimental hemorrhagic shock; evidence for development of a bacterial factor which accounts for irreversibility to transfusion and for the loss of the normal capacity to destroy bacteria.Am J Physiol. 1954 Dec;179(3):532-40 PMID: 13228624
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Resistance to bacteria in hemorrhagic shock. II. Effect of transient vascular collapse on sensitivity to endotoxin.Proc Soc Exp Biol Med. 1955 Apr;88(4):589-91 PMID: 14371709
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