The relation between sedation and body temperature in the mouse.

British journal of pharmacology and chemotherapy ·Vol. 12 ·No. 2 ·1957-06-00 ·Pages 245-50

LESSIN AW, PARKES MW

Abstract

Chlorpromazine and reserpine reduce locomotor activity and prolong pentobarbitone hypnosis in mice. Both these effects are shown to be proportional to the fall in body temperature produced by these drugs. Other agents are shown to reduce body temperature and potentiate pentobarbitone. At ambient temperatures of 32 degrees C. neither chlorpromazine nor reserpine is hypothermic or sedative. It is concluded that sedative effects in the mouse at ordinary room temperatures are related to the hypothermic properties of these drugs. At 36 degrees C., while reserpine fails to potentiate pentobarbitone, chlorpromazine still does so.

Keywords

BODY TEMPERATURE CHLORPROMAZINE/effects HYPNOTICS AND SEDATIVES/effects RESERPINE/effects

MeSH Terms

Anesthesia Animals Body Temperature Chlorpromazine/pharmacology Hypnotics and Sedatives/pharmacology Hypothermia Mice Pentobarbital Reserpine/pharmacology

Chemicals

Hypnotics and Sedatives Reserpine Pentobarbital Chlorpromazine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

LESSIN A W

PARKES M W

References (13)

13 references, click to expand

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Article Info

Journal

British journal of pharmacology and chemotherapy

Abbr.

Br J Pharmacol Chemother

ISSN

0366-0826

DOI

10.1111/j.1476-5381.1957.tb00128.x

Published

1957-06-00

Pages

245-50

Language

English

Region

England

NLM ID

0154627

PMCID

PMC1509669

Subset

External Links

PubMed source DOI: 10.1111/j.1476-5381.1957.tb00128.x PMC Full Text

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