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PMID: 13416527 Published · ppublish English Journal Article

Narcosis and emulsion reversal by inert gases.

The Journal of general physiology ·Vol. 40 ·No. 4 ·1957-03-20 ·Pages 515-20

SEARS DF, FENN WO

Abstract

Investigations of the effect of high pressures of Na (100 to 130 atmospheres) and of Ar (60 to 80 atmospheres) showed that these gases are effective in reversing the phases of an oil in water emulsion. Nitrous oxide did not cause reversal at pressures as high as 53 atmospheres nor did helium as high as 107 atmospheres. We found CO(2) most effective in reversing the emulsions and attributed this to its chemical properties. It is suggested that these observations may help to explain the narcotic effects of inert gases.

Keywords
ANESTHESIA INHALATION EMULSIONS GASES/effects
MeSH Terms
Anesthesia Anesthesia, Inhalation Emulsions Gases/pharmacology Helium Noble Gases Pressure Stupor
Chemicals
Emulsions Gases Noble Gases Helium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
SEARS D F
FENN W O
References (4)
4 references, click to expand
  1. Depressant action of inert gases on the central nervous system in mice.
    Am J Physiol. 1953 Feb;172(2):471-4 PMID: 13030774
  2. The cleavage times of fertilized eggs of the sea urchin, Arbacia punctulata, at high pressures of nitrogen, helium, and nitrous oxide.
    J Cell Physiol. 1953 Apr;41(2):335-43 PMID: 13052649
  3. Anesthetic action of inert and unreactive gases on intact animals and isolated tissues.
    Am J Physiol. 1954 Sep;178(3):505-9 PMID: 13207367
  4. Nitrogen narcosis in frogs and mice.
    Am J Physiol. 1951 Sep;166(3):699-711 PMID: 14885460
Article Info
Journal
The Journal of general physiology
Abbr.
J Gen Physiol
ISSN
0022-1295
Published
1957-03-20
Pages
515-20
Language
English
Region
United States
NLM ID
2985110R
PMCID
PMC2147636
Subset
OM
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