Reciprocal translocation, 4q-; 21p+, giving rise to Down's syndrome.

Journal of medical genetics ·Vol. 13 ·No. 4 ·1976-08-00 ·Pages 323-6

Jenkins MB, Boyd L

Abstract

A reciprocal translocation is described, t(4;21)(q27;p11), which occurs in a balanced carrier mother and her Down's syndrome child, 47,XX,t(4q-;21p+),+21. A review is presented of Down's syndrome associated with reciprocal translations involving chromosome No. 21.

MeSH Terms

Adult Chromosome Aberrations Chromosomes, Human, 21-22 and Y Chromosomes, Human, 4-5 Down Syndrome/genetics Female Humans Indians, North American Infant, Newborn Karyotyping Male Pedigree Translocation, Genetic

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Jenkins M B

Boyd L

References (19)

19 references, click to expand

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Article Info

Journal

Journal of medical genetics

Abbr.

J Med Genet

ISSN

0022-2593

DOI

10.1136/jmg.13.4.323

Published

1976-08-00

Pages

323-6

Language

English

Region

England

NLM ID

2985087R

PMCID

PMC1013425

Subset

External Links

PubMed source DOI: 10.1136/jmg.13.4.323 PMC Full Text View journal details

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Reciprocal translocation, 4q-; 21p+, giving rise to Down's syndrome.

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